The relationship between concentrations of magnesium and oxidized low-density lipoprotein and beta2-microglobulin in the serum of patients on the end-stage of renal disease
Joint Authors
Raikou, Vaia D.
Kyriaki, Despina
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 3 (30 Jun. 2016), pp.546-552, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
The end-stage of renal disease is associated with increased oxidative stress and oxidative modification of low-density lipoproteins (LDLs).
Beta2 microglobulin (beta2M) is accumulated in the serum of dialysis patients.
Magnesium (Mg) plays a protective role in the development of oxidative stress in healthy subjects.
We studied the relationship between concentrations of magnesium and oxidized LDL (ox-LDL) and beta2M in the serum of patients on the end stage of renal disease.
In 96 patients on on-line- predilution hemodiafiltration, beta2M and intact parathormone were measured by radioimmunoassays.
High-sensitivity C-reactive protein (hsCRP) and ox-LDL were measured using ΕLISA.
Serum bicarbonate levels were measured in the blood gas analyser gas machine.
We performed logistic regression analysis models to investigate Mg as an important independent predictor of elevated ox-LDL and high beta2M serum concentrations, after adjustment to traditional and specific for dialysis patients’ factors.
We observed a positive correlation of Mg with ox-LDL (r = 0.383, P = 0.001), but the association of Mg with beta2M, hsCRP, and serum bicarbonate levels was significantly inverse (r = −0.252, P = 0.01, r = −0.292, P = 0.004, and r = −0.282, P = 0.04 respectively).
The built logistic-regression analysis showed that Mg act as a significant independent factor for the elevated ox-LDL and beta2M serum concentrations adjusting to traditional and specific factors for these patients.
We observed a positive relationship between magnesium and acidosis statusrelated ox-LDL concentrations, but the inverse association between magnesium and beta2M serum concentrations in hemodialysis patients.
American Psychological Association (APA)
Raikou, Vaia D.& Kyriaki, Despina. 2016. The relationship between concentrations of magnesium and oxidized low-density lipoprotein and beta2-microglobulin in the serum of patients on the end-stage of renal disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 3, pp.546-552.
https://search.emarefa.net/detail/BIM-683642
Modern Language Association (MLA)
Raikou, Vaia D.& Kyriaki, Despina. The relationship between concentrations of magnesium and oxidized low-density lipoprotein and beta2-microglobulin in the serum of patients on the end-stage of renal disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 3 (May. / Jun. 2016), pp.546-552.
https://search.emarefa.net/detail/BIM-683642
American Medical Association (AMA)
Raikou, Vaia D.& Kyriaki, Despina. The relationship between concentrations of magnesium and oxidized low-density lipoprotein and beta2-microglobulin in the serum of patients on the end-stage of renal disease. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 3, pp.546-552.
https://search.emarefa.net/detail/BIM-683642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 551-552
Record ID
BIM-683642