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Effect of olea oleaster and juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice
Joint Authors
al-Rabbai, Ali A.
al-Maliki, Dakhl Allah A.
al-Attar, Atif M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 3 (31 May. 2016), pp.363-371, 9 p.
Publisher
Publication Date
2016-05-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
The effect of Olea oleaster and Juniperus procera leaves extracts and their combination on thioacetamide (TAA)-induced hepatic cirrhosis were investigated in male albino mice.
One hundred sixty mice were used in this study and were randomly distributed into eight groups of 20 each.
Mice of group 1 served as controls.
Mice of group 2 were treated with TAA.
Mice of group 3 were exposed to TAA and supplemented with O.
oleaster leaves extracts.
Mice of group 4 were treated with TAA and supplemented with J.
procera leaves extracts.
Mice of group 5 were subjected to TAA and supplemented with O.
oleaster and J.
procera leaves extracts.
Mice of groups 6, 7 and 8 were supplemented with O.
oleaster, J.
procera, and O.
oleaster and J.
procera leaves extracts respectively.
Administration of TAA for six and twelve weeks resulted in a decline in body weight gain and increased the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin.
Histopathological evaluations of hepatic sections from mice treated with TAA showed severe alterations including increase of fibrogenesis processes with structural damage.
Treatment of mice with these extracts showed a pronounced attenuation in TAA induced hepatic cirrhosis associated with physiological and histopathological alterations.
Finally, this study suggests that the supplementation of these extracts may act as antioxidant agents and could be an excellent adjuvant support in the therapy of hepatic cirrhosis
American Psychological Association (APA)
al-Attar, Atif M.& al-Rabbai, Ali A.& al-Maliki, Dakhl Allah A.. 2016. Effect of olea oleaster and juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice. Saudi Journal of Biological Sciences،Vol. 23, no. 3, pp.363-371.
https://search.emarefa.net/detail/BIM-689434
Modern Language Association (MLA)
al-Attar, Atif M.…[et al.]. Effect of olea oleaster and juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice. Saudi Journal of Biological Sciences Vol. 23, no. 3 (May. 2016), pp.363-371.
https://search.emarefa.net/detail/BIM-689434
American Medical Association (AMA)
al-Attar, Atif M.& al-Rabbai, Ali A.& al-Maliki, Dakhl Allah A.. Effect of olea oleaster and juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 3, pp.363-371.
https://search.emarefa.net/detail/BIM-689434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 370-371
Record ID
BIM-689434