Prevalence of merkel cell polyomavirus in Tehran : an age-specific serological study
Joint Authors
Vaziri, Mustafa Salihi
Vahabpour, Ruh Allah
Aghasadeghi, Muhammad Rida
Mohajel, Nasir
Nasimi, Maryam
Esghaei, Maryam
Monavari, Seyed Hamidreza
Keyvani, Husayn
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 5 (31 May. 2016), pp.1-7, 7 p.
Publisher
Publication Date
2016-05-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Several new types of polyomavirus have been discovered in recent years mainly because of the recent state-of-the-art detection technologies.
Among the polyomaviruses, Merkel cell polyomavirus (MCPyV) has attracted the most attention because of its possible role in the etiology of Merkel cell carcinoma, a rare but lethal form of skin cancer.
Objectives: This study aimed to determine age-specific seroprevalence of MCPyV in Tehran.
Patients and Methods: In this cross-sectional study, we collected 440 serum samples from healthy individuals 2 to 78 years of age who visited the Pasteur Institute’s clinic in Tehran, Iran, using a convenience sampling strategy.
We developed a virus-like particle-based enzyme-linked immunosorbent assay that uses VP1, the major capsid protein of MCPyV, to detect and quantitate serum antibodies to MCPyV.
We compared the prevalence of MCPyV between males and females and across eight age groups.
Results: A total of 255 (57.9%) of the serum samples were MCPyV positive.
The seroprevalence in children under 10 years of age was 25%.
The seroprevalence increased to 56% over the next decade of life (10 - 19 years of age).
The seroprevalence rate in males and females was 56.1% and 59.7% respectively, and a binary logistic regression showed no significant difference between males and females (P = 0.77).
However, the prevalence of MCPyV increased with age (P = 0.012).
American Psychological Association (APA)
Vahabpour, Ruh Allah& Aghasadeghi, Muhammad Rida& Vaziri, Mustafa Salihi& Mohajel, Nasir& Keyvani, Husayn& Nasimi, Maryam…[et al.]. 2016. Prevalence of merkel cell polyomavirus in Tehran : an age-specific serological study. Iranian Red Crescent Medical Journal،Vol. 18, no. 5, pp.1-7.
https://search.emarefa.net/detail/BIM-694763
Modern Language Association (MLA)
Vahabpour, Ruh Allah…[et al.]. Prevalence of merkel cell polyomavirus in Tehran : an age-specific serological study. Iranian Red Crescent Medical Journal Vol. 18, no. 5 (May. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-694763
American Medical Association (AMA)
Vahabpour, Ruh Allah& Aghasadeghi, Muhammad Rida& Vaziri, Mustafa Salihi& Mohajel, Nasir& Keyvani, Husayn& Nasimi, Maryam…[et al.]. Prevalence of merkel cell polyomavirus in Tehran : an age-specific serological study. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 5, pp.1-7.
https://search.emarefa.net/detail/BIM-694763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-694763