Assessment of breast carcinoma by 99mtc-sestamibi scintimammography : effect of lesion site, size and histopathological characteristics
Author
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 12, Issue 3 (30 Sep. 2000), pp.183-189, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2000-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
This study included 83 female patients with 94 breast lesions.
All patients underwent clinical examination, Xray mammography and 99mTc- MIBI scintimammography (SMM).
Furthermore, fine needle aspiration biopsy (FNAB) was performed for 53 breast lesions prior to surgical excision.
Complete agreement between histopathological diagnosis and SMM was observed in 66 / 80 (82.5 %) malignant lesions, whereas 2 / 14 (14 %) of benign lesions had false positive results and proved to be adenoma and granuloma.
The overall sensitivity, specificity and accuracy were 83 %, 85.5 % and 83 % respectively for SMM and 62.5 %, 59.3 % and 61.4 % for x ray mammography.
This difference was statistically significant (p = 0.006).
On the other had, sensitivity, specificity and accuracy of FNAB was 91.8 %, 90 % and 91 % respectively.
SMM and FNAB did not show much significant difference in their sensitivity, specificity and accuracy (p = 0.318).
The highest diagnostic sensitivity of SMM was 87 % for the detection of invasive carcinoma measuring 1- 2 cm.
However, the sensitivity was only 29 % for the detection of breast lesions less than 1 cm.
On contrast, X-ray mammography had a higher diagnostic sensitivity of 75 % for the detection of malignant breast lesions less than 1 cm.
99mTc-MIBI scintigraphy showed a higher sensitivity of 90 % and 89 % for the diagnosis of breast carcinoma grade 3 and 4 respectively.
While, it had a lower sensitivity of 67 % and 81% for the detection of malignant lesions grade 1 and 2 respectively.
The sensitivity of 99mTc-MIBI scintimammography was not influenced by tumour pathology (invasive ductal carcinoma was 85 % and invasive lobular carcinoma was 80 %) (p = 0.22).
Presence of carcinoma in situ did not affect the diagnostic accuracy of 99mTc- MIBI.
The sensitivity of SMM for the detection of invasive carcinoma with ER + ve was higher than that for the detection of invasive carcinoma with ER-ve (86 % vs 70 % respectively) (p < 0.05).
SMM had a significantly higher sensitivity (95 %) for localizing breast lesions in the retroareolar region compared to that in the other sites (lower inner quadrant 50 %, lower outer 70% and upper inner 82 %).
American Psychological Association (APA)
Sabri, Rafat A.. 2000. Assessment of breast carcinoma by 99mtc-sestamibi scintimammography : effect of lesion site, size and histopathological characteristics. Journal of the Egyptian National Cancer Institute،Vol. 12, no. 3, pp.183-189.
https://search.emarefa.net/detail/BIM-69486
Modern Language Association (MLA)
Sabri, Rafat A.. Assessment of breast carcinoma by 99mtc-sestamibi scintimammography : effect of lesion site, size and histopathological characteristics. Journal of the Egyptian National Cancer Institute Vol. 12, no. 3 (Sep. 2000), pp.183-189.
https://search.emarefa.net/detail/BIM-69486
American Medical Association (AMA)
Sabri, Rafat A.. Assessment of breast carcinoma by 99mtc-sestamibi scintimammography : effect of lesion site, size and histopathological characteristics. Journal of the Egyptian National Cancer Institute. 2000. Vol. 12, no. 3, pp.183-189.
https://search.emarefa.net/detail/BIM-69486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-189
Record ID
BIM-69486