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Treatment of aluminium phosphide poisoning with a combination of intravenous glucagon, digoxin and antioxidant agents
Other Title(s)
علاج تسمم فوسفيد الألومنيوم بمزيج من الغلوكاغون الوريدي و الديجوكسين و مواد مضادة للتأكسد
Joint Authors
Oghabian, Zahrah
Mehrpour, Umid
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 16, Issue 3 (31 Aug. 2016), pp.352-355, 4 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2016-08-31
Country of Publication
Oman
No. of Pages
4
Main Subjects
Topics
Abstract EN
Aluminium phosphide (AlP) is used to protect stored grains from rodents.
It produces phosphine gas (PH3), a mitochondrial poison thought to cause toxicity by blocking the cytochrome c oxidase enzyme and inhibiting oxidative phosphorylation, which results in cell death.
AlP poisoning has a high mortality rate among humans due to the rapid onset of cardiogenic shock and metabolic acidosis, despite aggressive treatment.
We report a 21-yearold male who was referred to the Afzalipour Hospital, Kerman, Iran, in 2015 after having intentionally ingested a 3 g AlP tablet.
He was successfully treated with crystalloid fluids, vasopressors, sodium bicarbonate, digoxin, glucagon and antioxidant agents and was discharged from the hospital six days after admission in good clinical condition.
For the treatment of AlP poisoning, the combination of glucagon and digoxin with antioxidant agents should be considered.
However, evaluation of further cases is necessary to optimise treatment protocols.
American Psychological Association (APA)
Oghabian, Zahrah& Mehrpour, Umid. 2016. Treatment of aluminium phosphide poisoning with a combination of intravenous glucagon, digoxin and antioxidant agents. Sultan Qaboos University Medical Journal،Vol. 16, no. 3, pp.352-355.
https://search.emarefa.net/detail/BIM-709682
Modern Language Association (MLA)
Oghabian, Zahrah& Mehrpour, Umid. Treatment of aluminium phosphide poisoning with a combination of intravenous glucagon, digoxin and antioxidant agents. Sultan Qaboos University Medical Journal Vol. 16, no. 3 (Aug. 2016), pp.352-355.
https://search.emarefa.net/detail/BIM-709682
American Medical Association (AMA)
Oghabian, Zahrah& Mehrpour, Umid. Treatment of aluminium phosphide poisoning with a combination of intravenous glucagon, digoxin and antioxidant agents. Sultan Qaboos University Medical Journal. 2016. Vol. 16, no. 3, pp.352-355.
https://search.emarefa.net/detail/BIM-709682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 352-355
Record ID
BIM-709682