Serum vaspin level in type 2 diabetic patients from Gaza Strip

Other Title(s)

مستوى الفازبين في مصل الدم لمرضى السكرى من النوع الثاني في قطاع غزة

Dissertant

al-Burnu, Najwa Talal Khamis

Thesis advisor

al-Kahlut, Kamal al-Abd Muhammad
Yasin, Majid Muhammad

Comitee Members

al-Habibi, Mahmud Ismail
Abid, Abd Allah Assaf

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2016

English Abstract

Background: Type 2 diabetes is prevalent in Gaza strip.

Recently, vaspin has been identified as interesting novel adipokine having insulin sensitizing effect.

However, the relationship between vaspin and type 2diabetes have not been adequately studied.

Objective: To assess serum vaspin level in type 2 diabetic patients from Gaza Strip, and its relationships with some biochemical variable.

Materials and methods: This case-control study comprised 88 type 2 diabetic patients (44 males and 44 females) and 88 healthy controls (44 males and 44 females).

Questionnaire interview was applied.

Serum vaspin, glucose, blood glycated hemoglobin (HbA1c), insulin, cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) were determined.

Data were computer analyzed using SPSS version 22.0.

Results: The mean ages of cases and controls were 45.9±7.1 and 45.8±7.0 years, respectively.

The mean level of vaspin was significantly higher in cases compared to controls (0.73±0.67 versus 0.47±0.43 ng/ml, P=0.033).

Obese diabetic patients showed higher vaspin levels compared to controls (0.99±0.7 versus 0.62±0.52 ng/ml, P=0.048).

Vaspin was also significantly increased in obese cases compared to non obese cases (0.99±0.7 versus 0.48±0.42 ng/ml, P=0.005).

The levels of blood HbA1c, serum glucose and HOMA-IR were significantly increased in cases compared to controls (6.7±1.3 versus 4.7±0.65%, P=0.000 and 189.6±79.1 versus 90.7±13.6 mg/dl, P=0.000, 8.0±7.3 versus 3.6±2.4, P=0.000, respectively).

The mean levels of triglycerides was significantly higher in cases compared to controls (187.6±133.8 versus 133.7±71.8 mg/dl, P=0.021) whereas HDL-C was significantly lower in cases (45.3±10.3 versus 50.8±13.8 mg/dl, P=0.039).

Serum vaspin levels showed significant positive correlations with BMI (r=0.280, P=0.008), HbA1c% (r=0.209, P=0.049), glucose (r=0.290, P =0.006 ), HOMA-IR (r=0.276, P=0.010), triglycerides (r=0.303, P=0.004) and ALT activity (r=0.434, P=0.000).

Conclusions: Serum vaspin was significantly higher in type 2 diabetic patients compared to controls.

Serum vaspin levels showed significant positive correlations with BMI, HbA1c, glucose, HOMA-IR, triglycerides and ALT.

Main Subjects

Biology

No. of Pages

90

Table of Contents

• APA
• MLA
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Language

English

Data Type

Arab Theses

Record ID

BIM-727238