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Angiotensin II type 1 receptor gene A1166C polymorphism was not associated with acute coronary syndrome in an Iranian population
Joint Authors
Delshad, Navid
Razavi Azarkhiavi, Kamal
Moohebati, Muhsin
Hassani, Mitra
Kasaian, Jamal
Etemadzadeh, Muhammad Rida
Alavi, Maryam Saadat
Behravan, Javad
Ghayour Mobarhan, Majid
Mirzaei, Hamid Reza
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 11 (30 Nov. 2016), pp.1-6, 6 p.
Publisher
Publication Date
2016-11-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background : There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS).
Objectives : The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population.
Patients and Methods : This cross-sectional study was conducted among 263 subjects (97 men and 166 women).
Patients (n = 128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran).
A 12-lead electrocardiograph plus creatine kinase MB (CK-MB) levels were used as the basis for the diagnosis of myocardial ischemia.
The control group was selected from age-matched healthy subjects (n = 135).
Non-enzymatic kits were used for extraction of DNA from blood samples.
Polymerase chain reaction (PCR) was performed to amplify the DNA fragments.
For restriction fragment length polymorphism (RFLP) determination, the DdeI enzyme was used to digest the amplified DNA fragments.
Statistical analyses were performed using SPSS version 13.0.
Results : There wasnostatistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (P > 0.05).
Conclusions : The AT1R A1166C polymorphism appeared not to be associated with the presence of ACS in the population studied.
American Psychological Association (APA)
Delshad, Navid& Ghayour Mobarhan, Majid& Mirzaei, Hamid Reza& Razavi Azarkhiavi, Kamal& Moohebati, Muhsin& Hassani, Mitra…[et al.]. 2016. Angiotensin II type 1 receptor gene A1166C polymorphism was not associated with acute coronary syndrome in an Iranian population. Iranian Red Crescent Medical Journal،Vol. 18, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-728727
Modern Language Association (MLA)
Delshad, Navid…[et al.]. Angiotensin II type 1 receptor gene A1166C polymorphism was not associated with acute coronary syndrome in an Iranian population. Iranian Red Crescent Medical Journal Vol. 18, no. 11 (Nov. 2016), pp.1-6.
https://search.emarefa.net/detail/BIM-728727
American Medical Association (AMA)
Delshad, Navid& Ghayour Mobarhan, Majid& Mirzaei, Hamid Reza& Razavi Azarkhiavi, Kamal& Moohebati, Muhsin& Hassani, Mitra…[et al.]. Angiotensin II type 1 receptor gene A1166C polymorphism was not associated with acute coronary syndrome in an Iranian population. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-728727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-728727