Characterization of undifferentiated malignant spindle cell tumors : a practical immunohistochemical study in Kurdistan region, Iraq
Other Title(s)
توصيف الأورام الخبيثة غير المتمايزة ذات الخلايا مغزليه الشكل : دراسة نسيجية مناعية عملية في إقليم كردستان العراق
Joint Authors
Pity, Intisar S.
Jalal, Jalal A.
Napaki, Sarbar ME.
Source
Journal of the Arab Board of Health Specializations
Issue
Vol. 13, Issue 4 (31 Dec. 2012), pp.24-33, 10 p.
Publisher
The Arab Board of Health Specializations
Publication Date
2012-12-31
Country of Publication
Syria
No. of Pages
10
Main Subjects
Abstract EN
Objective : The aim of this study was to evaluate the role of immunohistochemistry in characterization of undifferentiated malignant spindle cell tumors in Kurdistan region, Iraq.
Methods : The study extended from April 2008 to June 2010.
Overall, 102 cases were reported as undifferentiated malignant spindle cell tumors in the histopathology departments of Kurdistan region, Iraq.
Immunophenotyping done was streptavidin-biotin method on paraffin sections.
Results : In the studied sample, malignant spindle cell tumors were more frequently located in the bone and soft tissue (28.4 %), followed by gastrointestinal tract (17.6%) and respiratory tract (12.8 %), female genital tract formed (9.8 %), central nervous system (7.8 %), urinary tract (5.9 %), lymph nodes (4.9 %) and skin (3.9 %).
The remainder cases were (8.6 %) were miscellaneous.
Sarcoma group was at the top of the diagnosis list and the main bulk (50 %) followed by sarcomatoid carcinoma (10.8%), gastrointestinal stromal tumor (7.8 %) and melanoma (6.9 %).
Glioblastoma multiforme, malignant meningioma and mesothelioma were diagnosed in 2.9 % of cases each while monophasic Wilm’s tumor, yolk sac tumor and carcinosarcoma were found in 1.9 % of cases each.
by the increasing number of good quality antibodies in addition to the improvements in antigen retrieval techniques.8-13 Nonetheless, it is vital that the accuracy of clinical evaluation and morphologic differential diagnosis will definitely determine the success of IHC as a supplementary tool.1-8 In the current study, we present an overview of undifferentiated malignant spindle cell tumors in Kurdistan Region, Iraq with inconclusive clinico-morphological diagnosis and detail the immunohistochemical approach to these biopsies.
The occurrence of these tumors and the way in which they were distributed according to the localization were also evaluated
American Psychological Association (APA)
Pity, Intisar S.& Jalal, Jalal A.& Napaki, Sarbar ME.. 2012. Characterization of undifferentiated malignant spindle cell tumors : a practical immunohistochemical study in Kurdistan region, Iraq. Journal of the Arab Board of Health Specializations،Vol. 13, no. 4, pp.24-33.
https://search.emarefa.net/detail/BIM-747078
Modern Language Association (MLA)
Pity, Intisar S.…[et al.]. Characterization of undifferentiated malignant spindle cell tumors : a practical immunohistochemical study in Kurdistan region, Iraq. Journal of the Arab Board of Health Specializations Vol. 13, no. 4 (2012), pp.24-33.
https://search.emarefa.net/detail/BIM-747078
American Medical Association (AMA)
Pity, Intisar S.& Jalal, Jalal A.& Napaki, Sarbar ME.. Characterization of undifferentiated malignant spindle cell tumors : a practical immunohistochemical study in Kurdistan region, Iraq. Journal of the Arab Board of Health Specializations. 2012. Vol. 13, no. 4, pp.24-33.
https://search.emarefa.net/detail/BIM-747078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 32-33
Record ID
BIM-747078