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Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue
Joint Authors
Rahman, Nafisur
Haque, SK. Manirul
Azmi, Sayyid Najmul Hijaz
Rahman, Habibur
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 1 (31 Jan. 2017), pp.25-34, 10 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Abstract EN
Two optimized and validated spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in commercial dosage forms.
Method A is based on the reaction of tertiary amino group of the drug with N-bromosuccinimide in methanol-acetone medium resulting in the formation of a yellow coloredproduct, which absorbed maximally at 353 nm.
Method B involves the formation of a colored chloroform extractable ion-pair complex of the drug with bromothymol blue at pH 2.32 absorbing maximally at 400 nm.
Beer’s law is obeyed in the concentration ranges 50-600 and 2-55 ig mL^1 with molar absorptivity of 1.58 x 102 and 1.50 x 104 Lmol^1 cm^1 for methods A and B, respectively.
The regression analysis yields the calibration equations: A = 4.012 X 10^4 + 1.16 X 10^3 C and A = 9.612; 10 C for methods A and B, respectively.
The application of the proposed methods to commercial dosage forms is presented.
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American Psychological Association (APA)
Rahman, Nafisur& Haque, SK. Manirul& Azmi, Sayyid Najmul Hijaz& Rahman, Habibur. 2017. Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue. Journal of Saudi Chemical Society،Vol. 21, no. 1, pp.25-34.
https://search.emarefa.net/detail/BIM-747643
Modern Language Association (MLA)
Rahman, Nafisur…[et al.]. Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue. Journal of Saudi Chemical Society Vol. 21, no. 1 (Jan. 2017), pp.25-34.
https://search.emarefa.net/detail/BIM-747643
American Medical Association (AMA)
Rahman, Nafisur& Haque, SK. Manirul& Azmi, Sayyid Najmul Hijaz& Rahman, Habibur. Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 1, pp.25-34.
https://search.emarefa.net/detail/BIM-747643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34
Record ID
BIM-747643