The evaluation of the relationship between serum levels of interleukin-6 and interleukin-10 and metabolic acidosis in hemodialysis patients
Joint Authors
Zahed, Narges Sadat
Chehrazi, Saghar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 1 (28 Feb. 2017), pp.23-29, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-02-28
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Patients
- Evaluation
- Kidneys
- Diseases
- Hemodialysis
- Kidney failure
- Interleukin-10
- Interleukin-6
- Metabolic acidosis
Abstract EN
Chronic kidney disease is defined as progressive kidney dysfunction.
The levels of various cytokines increase in hemodialysis (HD) patients.
High levels of interleukins (ILs) and presence of metabolic acidosis are described as independent risk factors for morbidity and mortality in these patients.
This study was designed to evaluate the relationship between IL-6 and IL-10 and serum bicarbonate and metabolic acidosis in HD patients.
In this analytical crosssectional study, patients referred to the HD units of Loghman Hakim and Shahid Ashrafi Esfahani Hospitals were randomly selected.
Demographic and laboratory data, such as albumin, creatinine, calcium, phosphorus, parathormone, C-reactive protein, complete blood count, ferritin, ILs-6 and -10, and arterial blood gas analysis, were recorded for each patient.
The correlation between IL and serum bicarbonate and other variables were evaluated by SPSS software.
The patients were compared for the presence of acidosis and positivity for IL.
A total of 84 patients with a mean age of 60.98 years and mean body mass index of 24.86 kg/m2 were evaluated (53% male and 57% female).
The mean dialysis duration was 24.86 ± 3.98 months.
Overall, 41.7% of the patients had diabetes mellitus and 36.9% of them had hypotension.
The mean serum levels of IL-6 and IL-10 were 6.036 and 17.46 pg/ml, respectively.
There was a significant correlation between IL-6 and IL-10 levels and serum bicarbonate and the incidence of metabolic acidosis (P <0.05).
Based on the results, metabolic acidosis and bicarbonate could be considered prognostic factors to differentiate the increased levels of IL-6 and IL-10 and associated morbidity and mortality.
American Psychological Association (APA)
Zahed, Narges Sadat& Chehrazi, Saghar. 2017. The evaluation of the relationship between serum levels of interleukin-6 and interleukin-10 and metabolic acidosis in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 1, pp.23-29.
https://search.emarefa.net/detail/BIM-748863
Modern Language Association (MLA)
Zahed, Narges Sadat& Chehrazi, Saghar. The evaluation of the relationship between serum levels of interleukin-6 and interleukin-10 and metabolic acidosis in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 1 (Jan. / Feb. 2017), pp.23-29.
https://search.emarefa.net/detail/BIM-748863
American Medical Association (AMA)
Zahed, Narges Sadat& Chehrazi, Saghar. The evaluation of the relationship between serum levels of interleukin-6 and interleukin-10 and metabolic acidosis in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 1, pp.23-29.
https://search.emarefa.net/detail/BIM-748863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-29
Record ID
BIM-748863