The relationship between total antioxidants, c-reactive protein and other parameters in patients with acute myocardial infarction

Abstract EN

Objective : To evaluate the relationship between antioxidant status, C-reactive protein, Troponin I and cardiac performance in patients with acute myocardial infarction.

Methods : The study was conducted on thirty eight patients who were admitted in the Intensive cardiac care unit (ICCU) in Ibn-Sina Teaching Hospital in Mosul city from March to September 2007, of them 33 were males and 5 were females, and control group of 40 persons nearly matched with age, sex and body mass index of them 33 were males and 7 were females.

Demographic details and written informed consent were obtained for both groups; the diabetic and smokers were excluded Total antioxidants (TAS) measured by Peroxidase H2O2/ABTS Colorimetric Assay.

CRP measured by semi quantitative test procedure.

Troponin I assay was done by Monoclonal Antibody Technique and Enzyme Linked Immunoflourescent Assay.

Echocardiography done to all patients within the first 72 hours after the onset of chest pain.

Results : TAS was significantly low in patients with AMI (p<0.001), and was directly associated with ejection fraction (p<0.001).

CRP was significantly high in patient group (p<0.001).

CRP and EF value showed significant association; patients with EF<55 found to have a higher CRP level (p<0.03), and those with EF>55 have a lower CRP level (p<0.03).

Cardiac troponin I was found to have significant direct relationship with serum level of TAS (p<0.001).

Conclusions : Total antioxidant status (TAS) was significantly low in patients with AMI and was directly associated with ejection fraction and cardiac troponin I.