Effects of soybean oligosaccharides on intestinal microbial communities and immune modulation in mice
Joint Authors
Wu, Xingzhuang
Giovanni, Vigna
Meng, Xianjun
Ma, Yan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 1 (31 Jan. 2017), pp.114-121, 8 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Soybean oligosaccharides (SBOSs) are potential prebiotics that may be used to improve immune function.
Here, we investigated the effects of intragastric administration of SBOSs in mice to determine the effects on autochthonous intestinal microbial communities and immunological parameters.
Results E: After 22-day administration, 4.0 g kg body weight (BW)^1 SBOSs significantly enhanced the proliferation of bifidobacteria and lactic acid bacteria (LAB) as compared to the control.
This dose of SBOSs also significantly increased numbers of ente-rococci and decreased numbers of Clostridium perfringens.
Treatment with 4.0 g kg BW^1 SBOSs also significantly increased the percentage of T-lymphocytes and lymphocyte proliferation as compared to the control, suggesting that SBOSs promoted cellular immunity in mice.
Additionally, 4.0gkgBW^1 SBOSs induced significant differences in hemolysin production, natural killer (NK) cell activity, phagocytic activity, cytokine production, and immunoglobulin levels compared to the control.
Conclusion: Our data demonstrated that intragastric administration of SBOSs at a dose of 4.0 g kg BW^1 improved the numbers of beneficial intestinal microbes and enhanced immunological function of mice.
Therefore, these data supported that SBOSs may have applications as a prebiotic to improve immune responses in humans.
Further studies are warranted.
© 2016 The Authors.
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on behalf of King Saud University.
This is
American Psychological Association (APA)
Ma, Yan& Wu, Xingzhuang& Giovanni, Vigna& Meng, Xianjun. 2017. Effects of soybean oligosaccharides on intestinal microbial communities and immune modulation in mice. Saudi Journal of Biological Sciences،Vol. 24, no. 1, pp.114-121.
https://search.emarefa.net/detail/BIM-753671
Modern Language Association (MLA)
Ma, Yan…[et al.]. Effects of soybean oligosaccharides on intestinal microbial communities and immune modulation in mice. Saudi Journal of Biological Sciences Vol. 24, no. 1 (Jan. 2017), pp.114-121.
https://search.emarefa.net/detail/BIM-753671
American Medical Association (AMA)
Ma, Yan& Wu, Xingzhuang& Giovanni, Vigna& Meng, Xianjun. Effects of soybean oligosaccharides on intestinal microbial communities and immune modulation in mice. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 1, pp.114-121.
https://search.emarefa.net/detail/BIM-753671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 120-121
Record ID
BIM-753671