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Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice
Joint Authors
al-Rubai, Ali A.
al-Malki, Daklallah A.
al-Attar, Atif M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 1 (31 Jan. 2017), pp.15-22, 8 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
This study, for the first time, evaluates the effect of olive and juniper leaves extracts and their combination on thioacetamide (TAA)-induced nephrotoxicity in male mice.
The experimental mice were divided into eight groups.
Group 1 was served as control.
Group 2 was exposed to TAA.
Group 3 was treated with TAA and olive leaves extract.
Group 4 was subjected to TAA and juniper leaves extract.
Group 5 was exposed to TAA and olive and juniper leaves extracts.
Groups 6, 7 and 8 were treated with olive, juniper, and olive and juniper leaves extracts respectively.
In mice treated with only TAA, significant increases of blood urea nitrogen and uric acid were observed after six weeks.
Moreover, levels of serum creatinine, blood urea nitrogen and uric acid were statistically increased in mice administrated with only TAA for twelve weeks.
Insignificant alterations in levels of these haematobiochemical parameters were noted in other treated groups after six and twelve weeks.
Histopathological evaluations of renal sections from mice treated with only TAA for twelve weeks showed severe damage of the renal corpuscles.
Furthermore, the renal sections from mice treated with TAA and olive leaves extract, TAA and juniper leaves extract, TAA and olive and juniper leaves extracts, olive leaves extract, juniper leaves extract, and olive and juniper leaves extracts showed normal structures.
In addition, it is conceivable therefore, that these extracts exhibit protective influences against TAA-induced nephrotoxicity, probably mediated through the antioxidative pathway roles.
American Psychological Association (APA)
al-Attar, Atif M.& al-Rubai, Ali A.& al-Malki, Daklallah A.. 2017. Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice. Saudi Journal of Biological Sciences،Vol. 24, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-753853
Modern Language Association (MLA)
al-Attar, Atif M.…[et al.]. Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice. Saudi Journal of Biological Sciences Vol. 24, no. 1 (Jan. 2017), pp.15-22.
https://search.emarefa.net/detail/BIM-753853
American Medical Association (AMA)
al-Attar, Atif M.& al-Rubai, Ali A.& al-Malki, Daklallah A.. Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-753853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 21-22
Record ID
BIM-753853