Risk factors of rheumatoid arthritis development among females in north-west of Iran : a case-control study
Joint Authors
Shishavan, Neda Ghamarzad
Pirouzpanah, Said
Hajialilo, Mehrzad
Khabbazi, Ali Rida
Jafarpour, Farnaz
Mirtaheri, Ilham
Farrin, Nazila
Ibrahim Zadih, Sima
Baban, Navid
Shakiba, Zahra
Ghahreman Zadeh, Kazim
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 12 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-12-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background: Given the high prevalence of rheumatoid arthritis (RA) in females of reproductive ages, it seems that hormonal factors might be important in RA pathogenesis.
Objectives: The current study aimed to investigate the association between females’ reproductive factors occurring prior to the onset of rheumatoid arthritis and the risk of RA development.
Methods: This case-control study was conducted on 231 patients with RA and 238 controls among females aged 26 - 64 years old from the North-West of Iran.
The adjusted risk of RA was assessed using multivariate logistic regression models.
Results: Females 14 years old at menarche, were more likely to be at risk of RA (OR = 1.69; 95%CI: 1.08 - 2.64).
Advanced maternal age at first delivery (OR = 1.91; 95%CI: 1.21 - 3.26) and having abortion (OR = 1.97; 95%CI: 1.23 - 2.99) significantly increased the risk of RA.
Post-menopausal status increased the risk of developing RA (OR = 2.97; 95%CI: 1.98 - 4.46).
Longer duration of breast-feeding was determined as significant protective variable for RA (P < 0.05).
Subjects with oral contraceptives (OCs) use (OR = 0.36; 95% CI: 0.20 - 0.64), parity (OR = 0.20; 95%CI: 0.06 - 0.70) or large number of children tended to show rather more reduced risk of RA.
Conclusions: The risk of RA increased with delayed menarche, advanced maternal age at first delivery and early age at menopause.
However, longer duration of breast-feeding, parity, large number of children and consumption of OCs were found as protective independent variables against RA
American Psychological Association (APA)
Shishavan, Neda Ghamarzad& Pirouzpanah, Said& Hajialilo, Mehrzad& Khabbazi, Ali Rida& Jafarpour, Farnaz& Mirtaheri, Ilham…[et al.]. 2016. Risk factors of rheumatoid arthritis development among females in north-west of Iran : a case-control study. Iranian Red Crescent Medical Journal،Vol. 18, no. 12, pp.1-8.
https://search.emarefa.net/detail/BIM-758405
Modern Language Association (MLA)
Shishavan, Neda Ghamarzad…[et al.]. Risk factors of rheumatoid arthritis development among females in north-west of Iran : a case-control study. Iranian Red Crescent Medical Journal Vol. 18, no. 12 (Dec. 2016), pp.1-8.
https://search.emarefa.net/detail/BIM-758405
American Medical Association (AMA)
Shishavan, Neda Ghamarzad& Pirouzpanah, Said& Hajialilo, Mehrzad& Khabbazi, Ali Rida& Jafarpour, Farnaz& Mirtaheri, Ilham…[et al.]. Risk factors of rheumatoid arthritis development among females in north-west of Iran : a case-control study. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 12, pp.1-8.
https://search.emarefa.net/detail/BIM-758405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-758405