Evaluation of disease activity markers in relation to dry eye disease in patients with rheumatoid arthritis
Joint Authors
Abd al-Aziz, Dua M.
al-Mahdi, Amirah R.
Abd al-Rahim, Samiyah M.
Ubayd, Wiam M.
al-Kitkat, Raniya S.
al-Badawi, Muhjah A.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 44, Issue 3 (30 Sep. 2017), pp.111-117, 7 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2017-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Purpose The aim of this study was to correlate the presence of anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) antibodies with rheumatoid disease activity and dry eye disease in patients with rheumatoid arthritis (RA).
Patients and methods A total of 69 patients were evaluated for the activity of RA using the Disease Activity Score (DAS-28), erythrocyte sedimentation rate, and C-reactive protein.
We used the Health Assessment Questionnaire-Disability Index to assess functional disability.
Anti-CCP and anti-MCV antibodies were measured using enzymelinked immunosorbent assay technique.
We assessed dry eye symptoms using Ocular Surface Disease Index (OSDI) questionnaire.
Clinical tests used for dry eye assessment included Schirmer’s test, tear breakup time test, and ocular surface fluorescein staining.
Results Anti-CCP antibody serumlevels significantly correlated withDAS (r=0.46, P=0.036), Schirmer’s test (r=0.40, P=0.038), and ocular surface fluorescein staining (r=0.6, P=0.04).
Anti-MCV antibody serum levels correlated with DAS (r=0.5, P=0.04), ocular surface fluorescein staining (r=0.9, P=0.007), and OSDI score (r=0.3, P=0.03).
DAS showed a nonsignificant correlation with OSDI score and all tests of dry eye.
OSDI score significantly correlated with Schirmer’s test (P=0.036).
Conclusion Dry eye is themost common ocularmanifestation inour investigated patients with RA.
Dry eye disease existence is not correlated with disease activity, hence all patients with RA should be regularly examined for dye eye regardless of disease severity.
Rheumatologists could use the OSDI questionnaire for screening dry eye disease in patientswithRA.
The presence of anti-CCPand anti-MCVantibodies maydenote the existence of dry eye disease and correlates with RA disease activity.
American Psychological Association (APA)
al-Badawi, Muhjah A.& al-Mahdi, Amirah R.& Abd al-Rahim, Samiyah M.& Ubayd, Wiam M.& al-Kitkat, Raniya S.& Abd al-Aziz, Dua M.. 2017. Evaluation of disease activity markers in relation to dry eye disease in patients with rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation،Vol. 44, no. 3, pp.111-117.
https://search.emarefa.net/detail/BIM-760711
Modern Language Association (MLA)
al-Badawi, Muhjah A.…[et al.]. Evaluation of disease activity markers in relation to dry eye disease in patients with rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation Vol. 44, no. 3 (Jul. / Sep. 2017), pp.111-117.
https://search.emarefa.net/detail/BIM-760711
American Medical Association (AMA)
al-Badawi, Muhjah A.& al-Mahdi, Amirah R.& Abd al-Rahim, Samiyah M.& Ubayd, Wiam M.& al-Kitkat, Raniya S.& Abd al-Aziz, Dua M.. Evaluation of disease activity markers in relation to dry eye disease in patients with rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation. 2017. Vol. 44, no. 3, pp.111-117.
https://search.emarefa.net/detail/BIM-760711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 115-117
Record ID
BIM-760711