Sequential changes of serum and liver subcellular oxidants and antoxidant concentrations in silymarin treated male rats
Other Title(s)
التغيرات المتعاقبة لتراكيز المؤكسدات و مضاداتها في مصل و سوائل أكباد ذكور الجرذان المعاملة بالسليمارين
Joint Authors
Shuaybith, Husayn Jasim
al-Saidi, Jabbar Abbas Ahmad
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 30, Issue 1 (30 Jun. 2016), pp.9-14, 6 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
The present study aimed to investigate the role of silymarin as an antioxidant and/or it activity in induction of the endogenous antioxidants in intact adult male rats.
Seventy males were randomly devided into control and silymarin treated groups (35 each), and were drenched with drinking water and silymarin suspension (200 mg/ kg b.w) daily for 40 days.
Each group was allocated to 5 equal subgroups; sacrificed before treatment (0 day), and after 10, 20, 30, and 40 days of treatment.
At the end of each period, males were anaesthesized, dissected and blood samples were obtained for assessment of MDA, SOD, CAT and GSH concentrations.
liver samples (1 g) have been removed and homogenized for assessment of liver subcellular MDA, SOD, CAT and GSH concentrations.
At the end of each periods, serum and liver subcellular MAD concentrations showed no significant changes between groups, whereas SOD, CAT, and GSH concentrations significantly increased at 10, 20, 30, and 40 day periods in silymarin treated males compared with control.
It can be concluded that silymarin antioxidant activity is of pharmacological value not only as an antioxidant by itself but also as an inducer of endogenous enzymatic and non-enzymatic antioxidants even in normal intact male.
American Psychological Association (APA)
al-Saidi, Jabbar Abbas Ahmad& Shuaybith, Husayn Jasim. 2016. Sequential changes of serum and liver subcellular oxidants and antoxidant concentrations in silymarin treated male rats. Iraqi Journal of Veterinary Sciences،Vol. 30, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-761211
Modern Language Association (MLA)
al-Saidi, Jabbar Abbas Ahmad& Shuaybith, Husayn Jasim. Sequential changes of serum and liver subcellular oxidants and antoxidant concentrations in silymarin treated male rats. Iraqi Journal of Veterinary Sciences Vol. 30, no. 1 (Jun. 2016), pp.9-14.
https://search.emarefa.net/detail/BIM-761211
American Medical Association (AMA)
al-Saidi, Jabbar Abbas Ahmad& Shuaybith, Husayn Jasim. Sequential changes of serum and liver subcellular oxidants and antoxidant concentrations in silymarin treated male rats. Iraqi Journal of Veterinary Sciences. 2016. Vol. 30, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-761211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13-14
Record ID
BIM-761211