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Dexmedetomidine versus clonidine as an adjuvant to peribulbar block in vitreoretinal surgery
Joint Authors
al-Kabariti, Rim H.
Khashabah, Muhammad Y.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 5, Issue 3 (30 Sep. 2012), pp.288-294, 7 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2012-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To assess the efficacy, time to first analgesic request, total analgesic requirement, patients’ satisfaction, intraocular pressure (IOP), and side effects of addition of dexmedetomidine to a local anesthetic mixture for a peribulbar block in vitreoretinal surgery.
Methods A double-blind prospective study was carried out on 50 ASA I and II patients scheduled for elective vitreoretinal surgery.
Patients were divided randomly into two groups, 25 patients in each group.
Group C received equal volumes of 9 ml of a 1 : 1 mixture of bupivacaine 0.5% and lidocaine 2% with 1 mg/kg clonidine in 1 ml saline and group D received the same local anesthetic mixture supplemented with 1 mg/kg dexmedetomidine in 1 ml saline (total volume 10 ml).
The duration and onset of sensory and motor block, time to first analgesic request, total analgesic requirement, patients’ comfort, IOP, and other side effects of dexmedetomidine were assessed.
Results Patients who received dexmedetomidine showed significantly prolonged duration of lid, globe akinesia, and globe anesthesia (192.0 ± 34.9, 229.5 ±58.5, and 130.9 ± 30.5 min, respectively).
The measurement of IOP was significantly less in the dexmedetomidine group after 5 and 10 min.
The time to first analgesic requirement was statistically higher in the dexmedetomidine group (6.2 ±2.3 h), whereas the total analgesic requirement was significantly higher in the clonidine group.
More than 90% of dexmedetomidine patients were comfortable intraoperatively and postoperatively, with significantly less side effects of dryness of the mouth and dizziness.
Conclusion The addition of 1 mg/kg dexmedetomidne to the lidocaine–bupivacaine mixture in a peribulbar block for vitreoretinal surgery improves the duration of lid, globe akinesia, and anesthesia, with a significant decrease in the IOP.
It prolongs the time to first rescue analgesia and decreases the number of analgesic requirements, with minimal side effects in comparison with clonidine
American Psychological Association (APA)
al-Kabariti, Rim H.& Khashabah, Muhammad Y.. 2012. Dexmedetomidine versus clonidine as an adjuvant to peribulbar block in vitreoretinal surgery. Ain Shams Journal of Anesthesiology،Vol. 5, no. 3, pp.288-294.
https://search.emarefa.net/detail/BIM-761542
Modern Language Association (MLA)
al-Kabariti, Rim H.& Khashabah, Muhammad Y.. Dexmedetomidine versus clonidine as an adjuvant to peribulbar block in vitreoretinal surgery. Ain Shams Journal of Anesthesiology Vol. 5, no. 3 (Sep. 2012), pp.288-294.
https://search.emarefa.net/detail/BIM-761542
American Medical Association (AMA)
al-Kabariti, Rim H.& Khashabah, Muhammad Y.. Dexmedetomidine versus clonidine as an adjuvant to peribulbar block in vitreoretinal surgery. Ain Shams Journal of Anesthesiology. 2012. Vol. 5, no. 3, pp.288-294.
https://search.emarefa.net/detail/BIM-761542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 293-294
Record ID
BIM-761542