Mechanistic prediction of food effects for compound A tablet using PBPK model
Joint Authors
Yang, Lin
Shi, Lei
Li, Xueqing
Tang, Xiuling
Wang, Qinghui
Zhou, Lun
Feng, Zhijun
Ge, Jie
Li, Jian Kang
Wen, Aidong
Zhang, Yan
Song, Wei
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.603-609, 7 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
-Physiologically based pharmacokinetic (PBPK) modeling has been extensively used to study the factors of effect drug absorption, distribution, metabolize and extraction progress in human.
In this study, Compound A(CPD A) is a BCS Class II drug, which has been extensive applied in clinical as lipid-lowering drug, administered orally after food, they displayed positive food effects in human, A PBPK model was built to mechanistic investigate the food effect of CPD A tablet in our study.
By using gastroplusTM software, the PBPK models accurately predicted the results of food effects and predicted data were within 2-fold error of the observed results.
The PBPK model mechanistic illuminated the changes of pharmacokinetic values for the positive food effects of the compound in human.
Here in, the PBPK modeling which were combined with ACAT absorption models in it, successfully simulated the food effect in human of the drug.
The simulation results were proved that PBPK model can be able to serve as a potential tool to predict the food effect on certain oral drugs.
American Psychological Association (APA)
Li, Xueqing& Shi, Lei& Tang, Xiuling& Wang, Qinghui& Zhou, Lun& Song, Wei…[et al.]. 2017. Mechanistic prediction of food effects for compound A tablet using PBPK model. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.603-609.
https://search.emarefa.net/detail/BIM-761775
Modern Language Association (MLA)
Li, Xueqing…[et al.]. Mechanistic prediction of food effects for compound A tablet using PBPK model. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.603-609.
https://search.emarefa.net/detail/BIM-761775
American Medical Association (AMA)
Li, Xueqing& Shi, Lei& Tang, Xiuling& Wang, Qinghui& Zhou, Lun& Song, Wei…[et al.]. Mechanistic prediction of food effects for compound A tablet using PBPK model. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.603-609.
https://search.emarefa.net/detail/BIM-761775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 608-609
Record ID
BIM-761775