Effect of growth hormone on final height in children with idiopathic short stature : A UAE, eastern region experience
Joint Authors
Shadid, Faris
Mreish, Shirin
Kaplan, Walid
Source
Issue
Vol. 32, Issue 6 (30 Nov. 2017), pp.403-406, 4 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
Objectives: The use of growth hormone (GH) in idiopathic short stature (ISS) has been a subject of debate for the past two decades.
We sought to assess the effect of GH on final height (FH) in patients with ISS in our region, which has a high consanguinity rate, and compare it to the effect observed in GH deficient (GHD) patients.
Methods: We conducted a retrospective chart review from 1 January 2005 to 31 December 2013 for patients with ISS or GHD from the local United Arab Emirates population who received GH treatment and were followed-up regularly in our clinic.
The change in height Z-score at 12 months and FH were assessed within each group and between the two groups.
Results: Twenty-one patients with ISS and 29 patients with GHD were studied.
There was a significant change in height Z-score at 12 months and FH in both groups (p < 0.001).
The improvement in the ISS group was comparable to the response seen in GHD patients at 12 months (0.5±0.3 standard deviation score (SDS), and 0.5±0.4 SDS, respectively; p = 0.540).
The effect on FH was better in ISS group than the GHD group of all etiologies (1.3±0.6 SDS vs.
0.9±0.7 SDS, respectively; p = 0.050), there was no difference between the ISS and the subgroup of idiopathic GHD (1.3±0.5 SDS and 1.2±0.8 SDS, respectively).
Conclusions: In our local population, GH has a positive effect on the short-term growth and FH of children with ISS to the same extent that has been observed in children with idiopathic GH deficiency
American Psychological Association (APA)
Mreish, Shirin& Kaplan, Walid& Shadid, Faris. 2017. Effect of growth hormone on final height in children with idiopathic short stature : A UAE, eastern region experience. Oman Medical Journal،Vol. 32, no. 6, pp.403-406.
https://search.emarefa.net/detail/BIM-772629
Modern Language Association (MLA)
Mreish, Shirin…[et al.]. Effect of growth hormone on final height in children with idiopathic short stature : A UAE, eastern region experience. Oman Medical Journal Vol. 32, no. 6 (Nov. 2017), pp.403-406.
https://search.emarefa.net/detail/BIM-772629
American Medical Association (AMA)
Mreish, Shirin& Kaplan, Walid& Shadid, Faris. Effect of growth hormone on final height in children with idiopathic short stature : A UAE, eastern region experience. Oman Medical Journal. 2017. Vol. 32, no. 6, pp.403-406.
https://search.emarefa.net/detail/BIM-772629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 406
Record ID
BIM-772629