Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles
Joint Authors
Malapermal, Veshara
Botha, Izel
Krishna, Suresh Babu Naidu
Mbatha, Joyce Nonhlanhla
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1294-1305, 12 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The role of silver nanoparticles (AgNps) is an attractive proposition for advancing modern diabetes therapies and applied science.
Stable AgNps with a size range of 3–25 nm were synthesized using aqueous leaf extracts from Ocimum basilicum, Ocimum sanctum, and in combination.
The concentration of the extracts facilitated the reduction of silver nitrate that led to the rapid formation of AgNps at room temperature, indicating a higher reaction rate as opposed to harsh chemical methods, and high conversion energy usually involved in the synthesis.
The size, shape and elemental analysis were carried out using UV–Visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM–EDX), dynamic light scattering (DLS), and zeta potential whilst, Fourier transform infrared (FTIR) supported by gas chromatography mass spectroscopy (GC–MS) was used to identify the type of capping agents.
Inhibition of a-amylase and a-glucosidase enzymes retards the rate of carbohydrate digestion, thereby provides an alternative and a less evasive strategy of reducing postprandial hyperglycaemia in diabetic patients.
The AgNps derived from O.
sanctum and O.
basilicum, respectively displayed an inhibitory effect at 89.31 ± 5.32%, and 79.74± 9.51%, respectively, against Bacillus stearothermophilus a-glucosidase enzyme model, indicating an enhanced biocatalytic potential compared to their respective crude extracts and the control.
Furthermore, the emerging rate of infections in diabetic patients validates the need for the discovery of dual diabetes therapies.
As a result, the bioderived AgNps displayed antimicrobial activity against bacterial
American Psychological Association (APA)
Malapermal, Veshara& Botha, Izel& Krishna, Suresh Babu Naidu& Mbatha, Joyce Nonhlanhla. 2017. Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1294-1305.
https://search.emarefa.net/detail/BIM-776411
Modern Language Association (MLA)
Malapermal, Veshara…[et al.]. Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1294-1305.
https://search.emarefa.net/detail/BIM-776411
American Medical Association (AMA)
Malapermal, Veshara& Botha, Izel& Krishna, Suresh Babu Naidu& Mbatha, Joyce Nonhlanhla. Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1294-1305.
https://search.emarefa.net/detail/BIM-776411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1303-1305
Record ID
BIM-776411