Combined caffeine and cisplatin treatment induces synergistic cytotoxicity in hela cell line
Other Title(s)
الكافيين يعزز سمية علاج السيسبلاتين على خلايا سرطان عنق الرحم
Joint Authors
Aliwaini, Saib H.
Dawas, Sanabil A.
Abu Tayyim, Husam al-Din M.
al-Juju, Salsabil H.
Source
مجلة الجامعة الإسلامية للدراسات الطبيعية
Publisher
The Islamic University-Gaza Deanship of Research and Graduate Affairs
Publication Date
2017-03-31
Country of Publication
Palestine (Gaza Strip)
No. of Pages
7
Main Subjects
Topics
English Abstract
Cisplatin is a common alkylating anticancer agent that has been used to treat several cancers.
However, the efficiency of cisplatin treatment is limited due to the severe side effects and the resistance to the drug, which eventually results in treatment failure.
Caffeine is a natural ingredient contained in many food sources.
Caffeine has been shown to induce cell cycle arrest and apoptosis in different cancer cell types.
The effect of caffeine on cisplatin treatment on cervical cancer cells is not well known.
Here we examined the combined effect of caffeine and cisplatin in human Hela cells.
The cancer cells were exposed to different concentrations of caffeine and cisplatin and IC50’s were determined by MTT assay.
Cell number and viability were measured by cell counting and trypan blue assays.
Data obtained show that, caffeine treatment enhances the anti-proliferation effect of cisplatin and lowered the IC50 of cisplatin from 8.93 μM to be 2.75 μM.
These results suggest that caffeine-assisted chemotherapy is useful for cervical cancer treatment.
Data Type
Conference Papers
Record ID
BIM-778512
American Psychological Association (APA)
Aliwaini, Saib H.& Dawas, Sanabil A.& Abu Tayyim, Husam al-Din M.& al-Juju, Salsabil H.. 2017-03-31. Combined caffeine and cisplatin treatment induces synergistic cytotoxicity in hela cell line. . No. (s) (Mar. 2017), pp.250-256.غزة، فلسطين : الجامعة الإسلامية-غزة، عمادة شؤون البحث العلمي و الدراسات العليا،.
https://search.emarefa.net/detail/BIM-778512
Modern Language Association (MLA)
Aliwaini, Saib H.…[et al.]. Combined caffeine and cisplatin treatment induces synergistic cytotoxicity in hela cell line. . غزة، فلسطين : الجامعة الإسلامية-غزة، عمادة شؤون البحث العلمي و الدراسات العليا،. 2017-03-31.
https://search.emarefa.net/detail/BIM-778512
American Medical Association (AMA)
Aliwaini, Saib H.& Dawas, Sanabil A.& Abu Tayyim, Husam al-Din M.& al-Juju, Salsabil H.. Combined caffeine and cisplatin treatment induces synergistic cytotoxicity in hela cell line. .
https://search.emarefa.net/detail/BIM-778512