Effect of Zinc nanoparticles on oxidative stress-related genes and antioxidant enzyme activity in the brain of Oreochromis niloticus and tilapia zillii
Joint Authors
Afifi, Muhammad
Abu Zinada, Usamah A.
Sadiq, Salina
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 7 (30 Nov. 2017), pp.1672-1678, 7 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
This study was carried out to determine the median lethal concentrations (LC50) of Zinc nanoparticles (ZnNPs) on Oreochromis niloticus and Tilapia zillii.
The biochemical and molecular potential effects of ZnNPs (500 and 2000 lg L 1) on the antioxidant system in the brain tissue of O.
niloticus and T.
zillii were investigated.
Four hundred fish were used for acute and sub-acute studies.
ZnNP LC50 concentrations were investigated in O.
niloticus and T.
zillii.
The effect of 500 and 2000 lg L 1 ZnNPs on brain antioxidants of O.
niloticus and T.
zillii was investigated.
The result indicated that 69 h LC50 was 5.5± 0.6 and 5.6 ±0.4 for O.
nilotica and T.
zillii, respectively.
Fish exposed to 500 lg L 1 ZnNPs showed a significant increase in reduced glutathione (GSH), total glutathione (tGSH) levels, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activity and gene expression.
On the contrary, malondialdehyde (MDA) levels significantly decreased.
Meanwhile, fish exposed to 2000 lg L 1 ZnNPs showed a significant decrease of GSH, tGSH levels, SOD, CAT, GR, GPx and GST activity and gene expression.
On the contrary, MDA levels significantly increased.
It was concluded that, the 96 h LC50 of ZnNPs was 5.5± 0.6 and 5.6± 0.4 for O.
nilotica and T.
zillii, respectively.
ZnNPs in exposure concentrations of 2000 lg/L induced a deleterious effect on the brain antioxidant system of O.
nilotica and T.
zillii.
In contrast, ZnNPs in exposure concentrations of 500 lg L produced an inductive effect on the brain antioxidant system of O.
nilotica and T.
zillii.
American Psychological Association (APA)
Sadiq, Salina& Afifi, Muhammad& Abu Zinada, Usamah A.. 2017. Effect of Zinc nanoparticles on oxidative stress-related genes and antioxidant enzyme activity in the brain of Oreochromis niloticus and tilapia zillii. Saudi Journal of Biological Sciences،Vol. 24, no. 7, pp.1672-1678.
https://search.emarefa.net/detail/BIM-781618
Modern Language Association (MLA)
Sadiq, Salina…[et al.]. Effect of Zinc nanoparticles on oxidative stress-related genes and antioxidant enzyme activity in the brain of Oreochromis niloticus and tilapia zillii. Saudi Journal of Biological Sciences Vol. 24, no. 7 (Nov. 2017), pp.1672-1678.
https://search.emarefa.net/detail/BIM-781618
American Medical Association (AMA)
Sadiq, Salina& Afifi, Muhammad& Abu Zinada, Usamah A.. Effect of Zinc nanoparticles on oxidative stress-related genes and antioxidant enzyme activity in the brain of Oreochromis niloticus and tilapia zillii. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 7, pp.1672-1678.
https://search.emarefa.net/detail/BIM-781618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1678
Record ID
BIM-781618