Endoglin : a novel predictor of vascular complications in type 1 diabetic children and adolescents
Joint Authors
Hilal, Radwa G.
al-Wakil, Majid A.
al-Batal, Wail H.
al-Kasas, Ghadah M.
Amir, Ahmad F.
Amer, Marwah F.
Muhammad, Najwa Abd al-Ghaffar
Source
Journal of the Arab Society for Medical Research
Issue
Vol. 12, Issue 2 (31 Dec. 2017), pp.73-78, 6 p.
Publisher
Arab Society for Medical Research
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/aim The incidence of developing complicationsin type 1 diabetic children andadolescents is increased along with increased development of vascular complications.
Endoglin is a cell-surface coreceptor for the transforming growth factor β1 it is highly expressed in the endothelial cell having a crucial role in angiogenesis, indicating endothelial dysfunction and diabetic complications and pathologies.
The present study aims to assess serum endoglin levels in relation to vascular and endothelial dysfunction associated with type 1 diabetes in a group of children and adolescents.
Patients and methods This studywas conducted on 30 diabetic children and adolescents, aged 6–16 years, in addition to 30 healthy children served as a control group of matched age.
Clinical examination and anthropometric assessment were done for all children.
In addition, endoglin,metabolic lipid parameters, glycatedhemoglobin, and urinary albuminwere determined, in addition to ophthalmologic examination for diabetic retinopathy.
Results The levels of serum endoglin, systolic blood pressure Z-score, diastolic blood pressure Z-score, cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides in patients were significantly higher than in controls.
Endoglin levels were higher in cases with albuminuria and retinopathy compared with other cases.
Significant correlations were detected between endoglin and systolic blood pressure Z-score, diastolic blood pressure Z-score, cholesterol, triglycerides, low-density lipoprotein, glycated hemoglobin, and albuminuria.
Conclusion We conclude that endoglin can serve as a predictor of cardiovascular risk in pediatric population and other diabetes-associated complications such as retinopathy and albuminuria
American Psychological Association (APA)
al-Kasas, Ghadah M.& al-Wakil, Majid A.& Hilal, Radwa G.& Amir, Ahmad F.& al-Batal, Wail H.& Muhammad, Najwa Abd al-Ghaffar…[et al.]. 2017. Endoglin : a novel predictor of vascular complications in type 1 diabetic children and adolescents. Journal of the Arab Society for Medical Research،Vol. 12, no. 2, pp.73-78.
https://search.emarefa.net/detail/BIM-783293
Modern Language Association (MLA)
al-Kasas, Ghadah M.…[et al.]. Endoglin : a novel predictor of vascular complications in type 1 diabetic children and adolescents. Journal of the Arab Society for Medical Research Vol. 12, no. 2 (Jul. / Dec. 2017), pp.73-78.
https://search.emarefa.net/detail/BIM-783293
American Medical Association (AMA)
al-Kasas, Ghadah M.& al-Wakil, Majid A.& Hilal, Radwa G.& Amir, Ahmad F.& al-Batal, Wail H.& Muhammad, Najwa Abd al-Ghaffar…[et al.]. Endoglin : a novel predictor of vascular complications in type 1 diabetic children and adolescents. Journal of the Arab Society for Medical Research. 2017. Vol. 12, no. 2, pp.73-78.
https://search.emarefa.net/detail/BIM-783293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 77-78
Record ID
BIM-783293