Serum level of interleukin-22 in patients with psoriasis and its correlation with disease severity
Joint Authors
Hasab Allah, Ashraf
Twisy, Huwayda
Hufni, Iman R. M.
Mursi, Hanan
Source
Journal of Current Medical Research and Practice
Issue
Vol. 2, Issue 2 (31 Aug. 2017), pp.133-135, 3 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2017-08-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction Psoriasis is a Tcellmediated inflammatory disease where Thelper (Th) lymphocytes (Th1, Th17, and Th22) play an important role in its pathogenesis.
The aim of the present study was to assess the serum levels of interleukin (IL)22 and its correlation with disease severity.
Materials and methods The present study included 25 psoriatic patients and 25 healthy controls.
Using serum samples collected from psoriatic patients and healthy controls, the concentrations of IL‑22 were examined using ELISA kits.
The severity of psoriatic skin lesions was assessed using psoriasis area and severity index scores.
Results IL‑22 concentrations were significantly higher in psoriatic patients in comparison with the control group.
A significant, positive correlation between the concentrations of IL‑22 and the severity of psoriasis was found.
Conclusion The results of our study suggest that Th22 along with its cytokine responses may contribute to the skin and systemic inflammatory conditions characteristic of psoriasis.
It seems that early identification of soluble biomarkers and initiation of wellmatched treatment may prevent exacerbation and progression of psoriasis.
American Psychological Association (APA)
Hufni, Iman R. M.& Mursi, Hanan& Hasab Allah, Ashraf& Twisy, Huwayda. 2017. Serum level of interleukin-22 in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice،Vol. 2, no. 2, pp.133-135.
https://search.emarefa.net/detail/BIM-788339
Modern Language Association (MLA)
Hufni, Iman R. M.…[et al.]. Serum level of interleukin-22 in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice Vol. 2, no. 2 (May. / Aug. 2017), pp.133-135.
https://search.emarefa.net/detail/BIM-788339
American Medical Association (AMA)
Hufni, Iman R. M.& Mursi, Hanan& Hasab Allah, Ashraf& Twisy, Huwayda. Serum level of interleukin-22 in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice. 2017. Vol. 2, no. 2, pp.133-135.
https://search.emarefa.net/detail/BIM-788339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 135
Record ID
BIM-788339