Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy
Joint Authors
al-Musawi, Anwar Ghani
al-Hulw, Sabah Ali
al-Kabi, Abd al-Razzaq Hasan
Source
Issue
Vol. 17, Issue 1 (30 Jun. 2014), pp.55-61, 7 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Background: Diabetes mellitus is a condition associated with increased oxidative stress as a consequence of hyperglycemia.
Therefore, the use of antioxidants in people with diabetes has been advocated.
Vitamin E is the most prevalent naturally occurring anti-oxidant.
Aim: To evaluate the effect of the combination of angiotensin receptor blocker (ARB) and vitamin E on urine protein in patients with diabetic nephropathy.
Methods: One hundred and six patients with diabetic nephropathy, who visited the Alsader medical city in Najaf governorate and Al-Furat Al-Awsat general hospital in Kufa, were investigated, 39 of them are type 1diabetics, and 67 of them are type 2 diabetics.
Each patient was followed up for 3 months with valsartan (160mg/day), then for 3 months with addition of tocopherol (400mg).
At the screening visits, proteinuria was determined in two 24 h urine sample, arterial blood pressure was measured twice at ten minutes rest with 2 minutes interval and serum level of potassium, sodium & creatinine were determined.
Results: Proteinuria was significantly lowered when tocopherol 400mg was added to valsartan, as compared with valsartan without tocopherol.
Valsartan alone caused a mean reduction of 24 h urine protein of 27% from the baseline, while the addition of tocopherol caused a mean reduction of 24 hour proteinuria of 30% from result of valsartan.
That is mean the combination therapy of valsartan and tocopherol caused a reduction in proteinuria of 44% from baseline.
Conclusion: The current study suggests that combination therapy of ARB and vitamin E offers an additional antiproteinuric and nephroprotective effect.
Recommendation: Antioxidants, in particular vitamin E have promising nephroprotective effects.
However, studies on other antioxidants like vitamin C are needed in the efforts of prevention of diabetic nephropathy.
American Psychological Association (APA)
al-Kabi, Abd al-Razzaq Hasan& al-Hulw, Sabah Ali& al-Musawi, Anwar Ghani. 2014. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal،Vol. 17, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-790715
Modern Language Association (MLA)
al-Hulw, Sabah Ali…[et al.]. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal Vol. 17, no. 1 (2014), pp.55-61.
https://search.emarefa.net/detail/BIM-790715
American Medical Association (AMA)
al-Kabi, Abd al-Razzaq Hasan& al-Hulw, Sabah Ali& al-Musawi, Anwar Ghani. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal. 2014. Vol. 17, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-790715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 59-61
Record ID
BIM-790715