Formulation of cream and ointment for burns, scars, wounds and diaper rash treatment using natural wheat germ oil

Other Title(s)

تحضير كريم و مرهم لمعالجة الحروق و الجروح و آثارها و طفح الحفاض لدى الأطفال باستخدام زيت جنين القمح

Dissertant

al-Duri, Raghdah Zakariyya

Thesis advisor

al-Ani, Rad Jabir
al-Wakil, Jabbar Faraj

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2018

English Abstract

Burn, chronic wounds, scars and diaper rash are health problems that negatively affect the lives of millions of people worldwide.

Wheat germ oil (WGO) is one of the richest natural sources of vitamin E and contains a number of other health-beneficial bioactive compounds, including: polyunsaturated fatty acids, policosanol, squalene, B vitamins, and other mineral content, it is used as dietary supplement and phytosterols (like cholesterol).

Previous studies showed that wheat germ oil has anti- oxidant activity, anti- bacterial activity, which may promote wound healing in experimental animal.

The aim of this study is to assess the effectiveness, safety and cost effectiveness of using wheat germ oil as a cream or ointment formulation for burn, wounds, scars and diaper rash therapy.

Formulation of wheat germ oil as a cream and ointment with two different percentages 10% and 20%.In-vitro evaluation was performed by studying the stability of the final product, and testing the finished products (formulated germ wheat ointment and cream) on induced wounds of ratʼs skin.

This study was performed on male Sprague rats divided into seven groups (four treatment groups each of which four rats compared to three control groups each of which 4 rats).

Burn wound (2cm bottom diameter) was initiated in rats.

The study and follow up were continued for almost 4 weeks.

The result of this study showed significant reduction in both percentage and time for wound healing in the treated groups (10%, 20% wheat germ oil cream and ointment) compared to cold cream & zinc oxide ointment groups and comparable to the control groups.

According the experimental data, this study proofed that topical administration of wheat germ oil in cream and ointment has tremendous therapeutic effect in the treatment of burns, wound, scars, and diaper rush.

Main Subjects

Pharmacology

Topics

No. of Pages

80

Table of Contents

Table of contents.

Abstract

Abstract in Arabic.

Chapter One : Introduction

Chapter Two : Literature review

Chapter Three : Animal preparation, materials and methodology.

Chapter Four : Results

Chapter Five : Discussion.

Chapter Six : Conclusion and recommendation.

References.

American Psychological Association (APA)

al-Duri, Raghdah Zakariyya. (2018). Formulation of cream and ointment for burns, scars, wounds and diaper rash treatment using natural wheat germ oil. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832859

Modern Language Association (MLA)

al-Duri, Raghdah Zakariyya. Formulation of cream and ointment for burns, scars, wounds and diaper rash treatment using natural wheat germ oil. (Master's theses Theses and Dissertations Master). Isra University. (2018).
https://search.emarefa.net/detail/BIM-832859

American Medical Association (AMA)

al-Duri, Raghdah Zakariyya. (2018). Formulation of cream and ointment for burns, scars, wounds and diaper rash treatment using natural wheat germ oil. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832859

Language

English

Data Type

Arab Theses

Record ID

BIM-832859