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Rare suprasellar chordoid Meningioma with INI1 gene mutation
Joint Authors
al-Mawla, Imad Fadl
Giha, Raniya
Dayf, Sawsan A. H.
Hasan, Ahmad M.
al-Hasan, Lamya Ahmad Muhammad
Arbab, Muhammad Abd al-Rahman
Source
Sudan Journal of Medical Sciences
Issue
Vol. 12, Issue 3 (30 Sep. 2017), pp.198-206, 9 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2017-09-30
Country of Publication
Sudan
No. of Pages
9
Main Subjects
Abstract EN
Background : Chordoid Meningioma is a rare brain tumour characterized genetically by loss of genetic material from chromosome 22q at cytogenetic level resulting in mutation of NF2 gene.
Objectives and case report : In the present report, we described a rare case of suprasellar chordoid meningioma, which presented in a 32-year-old-woman.
Her only complain was throbbing headache.
Neurological examination showed left temporal hemianopia, decreased visual acuity (3 / 6), and no physical abnormalities related to Castleman syndrome were noted.
Cranial magnetic resonance (MR) images demonstrated a 28 x 15 mm mass in the sellar region, which showed iso-to low intensity that enhanced vividly after gadolinium with upwards displacement of the Optic chiasm.
Total surgical excision of the tumour was performed and subsequent histological examination of the tumour showed typical histology pattern of chordoid meningioma grade II according to the WHO classification system of meningiomas.
Genomic DNA was extracted and mutation analysis for INI1 gene using primer of exon 4, 5, 7, and 9 showed mutation involving exon 9.
|DNA sequencing showed heterozygosity C-T mutation in exon 9 of INI1 gene leading to change of amino acid serine to phenylalanine at (codon 63).
The details of this case are presented with a review of the literature.
American Psychological Association (APA)
al-Mawla, Imad Fadl& Giha, Raniya& Dayf, Sawsan A. H.& al-Hasan, Lamya Ahmad Muhammad& Hasan, Ahmad M.& Arbab, Muhammad Abd al-Rahman. 2017. Rare suprasellar chordoid Meningioma with INI1 gene mutation. Sudan Journal of Medical Sciences،Vol. 12, no. 3, pp.198-206.
https://search.emarefa.net/detail/BIM-834494
Modern Language Association (MLA)
al-Mawla, Imad Fadl…[et al.]. Rare suprasellar chordoid Meningioma with INI1 gene mutation. Sudan Journal of Medical Sciences Vol. 12, no. 3 (2017), pp.198-206.
https://search.emarefa.net/detail/BIM-834494
American Medical Association (AMA)
al-Mawla, Imad Fadl& Giha, Raniya& Dayf, Sawsan A. H.& al-Hasan, Lamya Ahmad Muhammad& Hasan, Ahmad M.& Arbab, Muhammad Abd al-Rahman. Rare suprasellar chordoid Meningioma with INI1 gene mutation. Sudan Journal of Medical Sciences. 2017. Vol. 12, no. 3, pp.198-206.
https://search.emarefa.net/detail/BIM-834494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 204-206
Record ID
BIM-834494