Chromium inhibits in vitro viability and steroidogenic in ram leydig cells
Other Title(s)
تأثير الكروم التثبيطي لحيوية و فعلية إنتاج الستيرويد في خلايا ليدك للكباش في الزجاج
Author
al-Bayati, Muhannad Abd al-Sattar Ali
Source
Basrah Journal of Veterinary Research
Issue
Vol. 16, Issue 2 (31 Dec. 2017), pp.1-25, 25 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
25
Main Subjects
Abstract EN
One of an ecological hazardous agent Chromium; Cr (VI), The present experiment in vitro design to examine the mechanism of Leydig cell functions of Cr (VI) in ram testis, Cr (VI) treated groups demising cell growth behavior of exponential phase was upset of feeding time to Leydig cell in a dose-dependent manner, and induced mitochondria-dependent ATP depletion and subsequently apoptosis.
Cr (VI) effect may be attributed, at least in part to DNA fragmentation increase DNA tail number and tail length of COMET as compared with control group.
Furthermore, the properties of cell-specific regulation of cell membrane integrity had reduced and determinant cell concentration drop an.d reflected on the testosterone concentration were decreased as concentration-dependent manner, In conclusion, our results display the Cr (VI) is cytotoxic and impairs both viability and steroidogenic functions of Leydig cells in ram testis via actually different pathway direct affecting of viability and indirect on steroidogenic activity, succeeding in testicular performance.
However, the definite modes of action of harmfulness are not evidently unknown and must be rechecked and studied in a different aspect.
American Psychological Association (APA)
al-Bayati, Muhannad Abd al-Sattar Ali. 2017. Chromium inhibits in vitro viability and steroidogenic in ram leydig cells. Basrah Journal of Veterinary Research،Vol. 16, no. 2, pp.1-25.
https://search.emarefa.net/detail/BIM-839902
Modern Language Association (MLA)
al-Bayati, Muhannad Abd al-Sattar Ali. Chromium inhibits in vitro viability and steroidogenic in ram leydig cells. Basrah Journal of Veterinary Research Vol. 16, no. 2 (2017), pp.1-25.
https://search.emarefa.net/detail/BIM-839902
American Medical Association (AMA)
al-Bayati, Muhannad Abd al-Sattar Ali. Chromium inhibits in vitro viability and steroidogenic in ram leydig cells. Basrah Journal of Veterinary Research. 2017. Vol. 16, no. 2, pp.1-25.
https://search.emarefa.net/detail/BIM-839902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 19-25
Record ID
BIM-839902