Association of insulin growth factor-1 and growth hormone levels in elderly renal transplant recipients with cardiac dysfunction
Joint Authors
Sadiq, Khalid M.
Sulayman, Amin R.
Sulayman, Mahmud A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 1 (28 Feb. 2019), pp.62-67, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Insulin growth factor-1 (IGF-1) and growth hormone (GH) have cardiac protective effects through many mechanisms; they can directly oppose endothelial dysfunction in a number of ways.
Many studies assessed the effect of GH or IGF-like growth factor 1 in patients with cardiac dysfunction, but no previous study assessed the GH and insulin-like growth factor-1 in renal transplant recipients with and without cardiac dysfunction, especially elderly.
Eighty patients with renal transplantation and age limit above 75 years.
They were subdivided into two groups according to the presence or absence of cardiac dysfunction based on medical history, clinical findings, electrocardiogram, and echocardiography.
Serum GH and insulin-like growth factor-1 were studied by immunoradiometric assay.
The echocardiography study was performed.
M-mode two-dimensional and Doppler measurements were taken to obtain the four- and five- chamber views, chambers’ dimensions, left ventricular end-diastolic dimensions, left ventricular end-systolic dimensions, septal wall thickness (SWT), distance between leading edges of the endocardial and pericardial echoes of left ventricular posterior wall (posterior wall thickness), aortic root and left atrial dimensions (LAD), fractional shortening and ejection fraction.
IGF-1 is lower in patients with cardiac dysfunction with renal transplantation with mean value of 61 ± 30.05 than those control group with mean value 145.52 ± 70.5.
Level of human growth factor is higher in patients with dysfunction with renal transplantation with mean value 2.62 ± 3.05 than those control group after renal transplantation with mean value 0.85 ± 0.9.
No correlations were found between IGF-1 and various echocardiographic parameters.
Only SWT and LAD were negatively correlated with GH, r = −0.08, P ˂0.02, r = −0.37, P ˂0.03, respectively.
No correlation was found between IGF-1 and various echocardiographic parameters.
Only SWT and LAD were negatively correlated with GH
American Psychological Association (APA)
Sulayman, Amin R.& Sulayman, Mahmud A.& Sadiq, Khalid M.. 2019. Association of insulin growth factor-1 and growth hormone levels in elderly renal transplant recipients with cardiac dysfunction. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.62-67.
https://search.emarefa.net/detail/BIM-887115
Modern Language Association (MLA)
Sulayman, Amin R.…[et al.]. Association of insulin growth factor-1 and growth hormone levels in elderly renal transplant recipients with cardiac dysfunction. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.62-67.
https://search.emarefa.net/detail/BIM-887115
American Medical Association (AMA)
Sulayman, Amin R.& Sulayman, Mahmud A.& Sadiq, Khalid M.. Association of insulin growth factor-1 and growth hormone levels in elderly renal transplant recipients with cardiac dysfunction. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.62-67.
https://search.emarefa.net/detail/BIM-887115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67
Record ID
BIM-887115