Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant : case report and literature review
Joint Authors
Paolucci, Aldo
Antonelli, Barbara
Cerutti, Roberta
Donato, Francesca Maria
Lampertico, Pietro
Messa, Piergiorgio
Fabrizi, Fabrizio
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 1 (28 Feb. 2019), pp.239-249, 11 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Topics
Abstract EN
Chronic hepatitis C virus (HCV) infection is associated with numerous extra- hepatic complications, including neurological and renal manifestations.
We describe the case of a 67-year-old Caucasian man with HCV-associated cryoglobulinemic glomerulonephritis, cirrhosis, and hepatocellular carcinoma.
The early posttransplant course was complicated by fibrosing cholestatic hepatitis due to recurrent HCV in the graft (HCV RNA up to 44,944,438 IU/mL).
Proliferative glomerulonephritis (nephritic and nephrotic syndrome) with mixed cryoglobulinemia (purpura) was also recorded.
Seventy-two days after surgery, the patient presented with seizures and arterial hypertension; brain magnetic resonance imaging indicated the diagnosis of posterior reversible encephalopathy syndrome (PRES).
PRES responded well to medical treatment with complete resolution of neurological changes.
Antiviral therapy (sofosbuvir and ribavirin, six months) gave a sustained viral response with the improvement of cryoglobulinemic symptoms (including glomerular disease).
Repeat liver biopsy revealed the regression of cholestatic damage and perisinusoidal fibrosis.
The current follow-up shows stable chronic renal failure (serum creatinine: 1.4 mg/dL) and mild nephritic syndrome.
The impact of extrahepatic manifestations of HCV on patient outcomes is highlighted from novel observational studies reporting a relationshipa diseases are underway
American Psychological Association (APA)
Fabrizi, Fabrizio& Paolucci, Aldo& Antonelli, Barbara& Cerutti, Roberta& Donato, Francesca Maria& Lampertico, Pietro…[et al.]. 2019. Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant : case report and literature review. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.239-249.
https://search.emarefa.net/detail/BIM-887136
Modern Language Association (MLA)
Fabrizi, Fabrizio…[et al.]. Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant : case report and literature review. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.239-249.
https://search.emarefa.net/detail/BIM-887136
American Medical Association (AMA)
Fabrizi, Fabrizio& Paolucci, Aldo& Antonelli, Barbara& Cerutti, Roberta& Donato, Francesca Maria& Lampertico, Pietro…[et al.]. Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant : case report and literature review. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.239-249.
https://search.emarefa.net/detail/BIM-887136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 246-249
Record ID
BIM-887136