Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats
Joint Authors
al-Qahtani, Wahid H.
Bin Ubayd, Manal Abd al-Aziz
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 4 (31 May. 2019), pp.647-652, 6 p.
Publisher
Publication Date
2019-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Spirulina platensis has been advocated as safe food for human use by several investigators.
In this study its beneficial dietary effect against liver injuries caused by D-galactosamine (D-GalN) was studied ensuring safety to human health using animal model.
Acute hepatotoxicity was induced in Wister rats with DGalN followed by treatment with butylated hydroxytoluene (BHT) and with Spirulina aqueous extract at various concentrations.
The effect of Spirulina at different concentrations were tried and compared with BHT treatment.
The animals treated with D-GalN on subsequent treatment by supplementation with Spirulina (6, 9%) in the diets, led to significant reversal in the levels of the antioxidant enzymes through hepatocytes by suppression of negative effect.
Spirulina aqueous extract at 9% resulted in a significant decrease in the levels of alkaline phosphatase and infalmatory markers TNFa, IL6 and IL1b and also decreased TBARS, while it showed an increase in oxidative stress marker such as GR, GSH, GST, SOD, GPX and CAT and total protein when compared to the levels recorded with that group treated with DGalN.
Results also indicated that Spirulina aqueous extract at 9% concentration was equally effective in protecting liver damage as it was observed with BHT.
Histological studies on liver treated with D-GalN, BHT and Spirulina aqueous extract showed that S.
platensis is effective as diet in providing beneficial protective effect.
The results obtained in the present study very clearly indicated the positive beneficial protective effect of Spirulina, when used as diet, on the safety and protection of liver from injuries caused by toxicants.
American Psychological Association (APA)
al-Qahtani, Wahid H.& Bin Ubayd, Manal Abd al-Aziz. 2019. Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats. Saudi Journal of Biological Sciences،Vol. 26, no. 4, pp.647-652.
https://search.emarefa.net/detail/BIM-890906
Modern Language Association (MLA)
al-Qahtani, Wahid H.& Bin Ubayd, Manal Abd al-Aziz. Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats. Saudi Journal of Biological Sciences Vol. 26, no. 4 (May. 2019), pp.647-652.
https://search.emarefa.net/detail/BIM-890906
American Medical Association (AMA)
al-Qahtani, Wahid H.& Bin Ubayd, Manal Abd al-Aziz. Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 4, pp.647-652.
https://search.emarefa.net/detail/BIM-890906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 652
Record ID
BIM-890906