Effect of sertraline and fluoxetine on some biochemical parameters and histological changes in male and female laboratory rats Rattus norvegicus

Abstract EN

The current study was designed to determine the effect of sertraline and fluoxetine drugs on some biochemicals and histologicals change of male and female rats.

The animals were divided into five groups (each group consisting of 5 males and 5 females), the first group (control) was injected with the physiological solution Nacl 0.9%, second group was injected with10 mg / kg of Sertraline, third group was injected with 20 mg / kg of sertraline, fourth group was injected with 5 mg / kg of fluoxetine and fifth group was injected with10 mg / kg fluoxetine.

The results showed that a significant increase (P≤0.05) in the concentration of urea and creatinine (except for the second group of females) in all treated group compared with control.

In the liver enzymes, the results showed that a significant decrease in the concentrations of aspartate transaminase enzyme, Alanine transaminase and alkaline phosphatase in all treated groups compared with the control group(P≤0.05).

The kidney tissue showed histological changes such as infiltration of inflammatory cell, congestion, hemorrhage, renal glomerular distraction and loss, renal tubular hypertrophy.