Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children
Joint Authors
Erol, Meltem
Gayret, Ozlem Bostan
Nacaroglu, Hikmat Tekin
Sener, Ahmet
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 7 (31 Jul. 2019), pp.1-6, 6 p.
Publisher
Publication Date
2019-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a specific immuneand inflammatory mechanism.
This study investigates inflammatory biomarkers and their correlation with disease severity.
Objectives: The aim of this study is to determine the relationship between platelet parameters [(mean platelet volume (MPV), platelet distribution width (PDW)], the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and AD severity in children.
Methods: In this retrospective study, we reviewed patients diagnosed with AD and a healthy control group at the department of pediatrics at Health Sciences in a university-affiliated hospital in Istanbul, Turkey, between January 2015 and December 2016.
The study included 79 children with AD and 75 healthy controls.
AD severity was graded using the Scoring Atopic Dermatitis (SCORAD) index.
Complete blood count was measured, and NLR and PLR were calculated.
NLR, PLR, MPV, PDW were compared between AD patients and healthy controls, and the correlations between these indexes and clinical characteristics were analyzed.
Results: No significant difference was observed between patients and controls for MPV, NLR, and PLR (P = 0.708, P = 0.340, P = 0.179, respectively).
In the AD group, PDW was lower than controls (17.391.45, 18.041.65, P = 0.006).
In the severe AD group, MPV was higher (7.621.81, 6.641.16, P = 0.035) and PDW was lower than in the mild AD group (16.521.49, 17.931.44, P = 0.0001).
Conclusions: Mean MPV and PDW levels are correlated with atopic dermatitis severity in children.
American Psychological Association (APA)
Gayret, Ozlem Bostan& Nacaroglu, Hikmat Tekin& Erol, Meltem& Sener, Ahmet. 2019. Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children. Iranian Red Crescent Medical Journal،Vol. 21, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-892349
Modern Language Association (MLA)
Gayret, Ozlem Bostan…[et al.]. Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children. Iranian Red Crescent Medical Journal Vol. 21, no. 7 (Jul. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-892349
American Medical Association (AMA)
Gayret, Ozlem Bostan& Nacaroglu, Hikmat Tekin& Erol, Meltem& Sener, Ahmet. Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-892349
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in .
Record ID
BIM-892349