Lupus nephritis : an experience of a tertiary care center in Nepal
Joint Authors
Tripathi, Prashant Mani
Bartaula, Bijay
Subedi, Manish
Dakhal, Sushil
Mudbhari, Bandana
Sharma, Sanjib Kumar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 2 (30 Apr. 2019), pp.462-469, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-04-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Lupus nephritis (LN) is one of the common complications of systemic lupus erythematosus (SLE).
Timely treatment will decrease progression to chronic kidney disease.
Treatment varies with different stages for which biopsy is needed.
Controversies still exist regarding its requirement in management.
This is a retrospective study from September 2014 to August 2016 in B.
P.
Koirala Institute of Health Sciences, Dharan, Nepal among all patients with SLE and undergone renal biopsy.
Of 92 patients, most were female 85 (92.4%) with a median age of 32 years.
In this study, 80.4% had some clinical symptomatology.
Of the clinical manifestations, 41.3% had polyarthritis, edema (20.7%), and malar rash (17.4%).
Anti-nuclear antibody was positive in 80.4% and ds DNA in 70.7%.
Renal biopsy showed more number of patients 27 (35%) had Stage IV LN, followed by Stage I, 19 (24%), and Stage II, 16 (20%) LN.
Median urinary protein in Class I was 1.05 g, Class II (0.63 g), Class III (1.5 g), Class IV (2.44 g), Class V (3.99 g), and Class VI (4.7 g).
Only Stage IV had Kappa of 0.269 (P = 0.003) showing agreement between proteinuria and histological staging which was statistically significant (P <0.005).
However, overall Kappa analysis showed none to fair strength of agreement for different stages of LN (−0.014–0.269) with proteinuria.
Kappa (k) analysis showed none to fair strength of agreement for different stages of LN and proteinuria.
Hence, only proteinuria is not sufficient to replace the need of renal biopsy in LN.
American Psychological Association (APA)
Bartaula, Bijay& Subedi, Manish& Dakhal, Sushil& Mudbhari, Bandana& Tripathi, Prashant Mani& Sharma, Sanjib Kumar. 2019. Lupus nephritis : an experience of a tertiary care center in Nepal. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 2, pp.462-469.
https://search.emarefa.net/detail/BIM-895404
Modern Language Association (MLA)
Bartaula, Bijay…[et al.]. Lupus nephritis : an experience of a tertiary care center in Nepal. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 2 (Mar. / Apr. 2019), pp.462-469.
https://search.emarefa.net/detail/BIM-895404
American Medical Association (AMA)
Bartaula, Bijay& Subedi, Manish& Dakhal, Sushil& Mudbhari, Bandana& Tripathi, Prashant Mani& Sharma, Sanjib Kumar. Lupus nephritis : an experience of a tertiary care center in Nepal. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 2, pp.462-469.
https://search.emarefa.net/detail/BIM-895404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 467-469
Record ID
BIM-895404