Serum organochlorine pesticides residues and risk of cancer : a case-control study
Joint Authors
Amin, Muhammad
Yusuf, Mashitah M.
Tahir, Muhammad
Navid Ahmad
Ansari, Muhammad Javid
Anjum, Sayyid Ishtiyaq
Khan, Shahid Allah
Ata Allah, Muhammad
Shawkat, Suhayl
Buneri, Islam Dad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 7 (30 Nov. 2018), pp.1284-1290, 7 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Organochlorine pesticides (OCPs) are frequently used worldwide as insecticides, fungicides, herbicides and termiticides and have been associated with a variety of cancers in animal and human studies.
In the present study, we examined residues of fourteen OCPs in the serum samples of diagnosed cancer patients and healthy residents of Karachi, Pakistan.
A random collection of fasting blood samples was carried out from the donors with informed consent.
Serum was separated within 2 h of blood collection and was then subjected to extraction with organic solvents followed by purification with florisil column.
The final organic extract of each serum sample was processed with Gas Chromatograph coupled with Electron Capture Detector (GC-ECD).
OCPs were detected in 97.59% of the cancer cases and 93.75% of the healthy subjects.
Mean concentrations of total OCPs (ROCPs) was found elevated in the cancer group (0.606 mg/kg) compared with the control group (0.322 mg/kg).
Endosulfan was the highest prevalent OCP with a mean concentration of 0.214 mg/kg in the cancer group and 0.166 mg/kg in the control group.
The second most prevalent OCP was 4,4-DDE with a mean concentration of 0.131 mg/kg in the cancer group and 0.019 mg/kg in the control group.
Highest level of ROCPs was detected in the breast cancer cases (20.411 mg/kg) with a mean level of (2.041 mg/kg).
In light of the obtained results and available literature on the subject, it has been concluded that OCPs are positively associated with the risk of various cancers in humans
American Psychological Association (APA)
Ata Allah, Muhammad& Yusuf, Mashitah M.& Shawkat, Suhayl& Anjum, Sayyid Ishtiyaq& Ansari, Muhammad Javid& Buneri, Islam Dad…[et al.]. 2018. Serum organochlorine pesticides residues and risk of cancer : a case-control study. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1284-1290.
https://search.emarefa.net/detail/BIM-896315
Modern Language Association (MLA)
Ata Allah, Muhammad…[et al.]. Serum organochlorine pesticides residues and risk of cancer : a case-control study. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1284-1290.
https://search.emarefa.net/detail/BIM-896315
American Medical Association (AMA)
Ata Allah, Muhammad& Yusuf, Mashitah M.& Shawkat, Suhayl& Anjum, Sayyid Ishtiyaq& Ansari, Muhammad Javid& Buneri, Islam Dad…[et al.]. Serum organochlorine pesticides residues and risk of cancer : a case-control study. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1284-1290.
https://search.emarefa.net/detail/BIM-896315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1289-1290
Record ID
BIM-896315