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Predictors of coronary calcification in Indian hemodialysis patients
Joint Authors
Jamale, Tukaram
Hase, Niwrutti K.
Jasani, Rachana
Dedhia, Paras
Bajpai, Divya
Kumar, Rajesh
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 4 (31 Aug. 2018), pp.822-827, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-08-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Several biomolecules potentially serve as promoters or inhibitors of calcification in dialysis patients which include fetuin A, matrix gla protein, osteopontin, osteoprotegerin, etc.
The primary aim was to compare the biomarkers of coronary artery calcification (CAC) and to study its role as predictors of CAC in hemodialysis (HD) patients.
Of 126 patients undergoing chronic HD, 100 patients completed the study.
Blood samples were drawn for serum creatinine, electrolytes, calcium, phosphorus, Vitamin D3, parathyroid hormone (PTH), lipid profile, high sensitivity C-reactive protein, ferritin, fetuin A, and fibroblast growth factor-23 (FGF-23).
Noncontrast Computed Tomography scan of the coronary arteries was conducted on all participants.
Participants who were positive for CAC (P group) were compared with those negative for CAC (N group) using two sample t-test.
Multiple logistic regression analysis was conducted to determine the predictors of CAC.
The prevalence of vascular calcification (VC) was 60% with higher prevalence seen in males (71%), older age group, patients with dialysis vintage >5 years (27%), and diabetic population (62%).
Mean serum phosphorus was significantly higher (P <0.001) and fetuin A (P <0.001) was significantly lower in the P group.
Age (OR: 1.2, P = 0.004), serum phosphorus (OR: 1.8, P = 0.024), and fetuin A (OR: 0.0006, P = 0.001) were found as predictors of CAC.
CAC was more prevalent in males, patients with higher age group and in those with longer dialysis vintage and diabetic population.
Participants with CAC exhibited significantly high phosphorus and low fetuin A levels.
Age, phosphorus level, and fetuin A were found to be predictors of CAC in dialysis patients.
FGF-23 could not predict CAC.
American Psychological Association (APA)
Jasani, Rachana& Hase, Niwrutti K.& Kumar, Rajesh& Dedhia, Paras& Jamale, Tukaram& Bajpai, Divya. 2018. Predictors of coronary calcification in Indian hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 4, pp.822-827.
https://search.emarefa.net/detail/BIM-896523
Modern Language Association (MLA)
Jasani, Rachana…[et al.]. Predictors of coronary calcification in Indian hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 4 (Jul. / Aug. 2018), pp.822-827.
https://search.emarefa.net/detail/BIM-896523
American Medical Association (AMA)
Jasani, Rachana& Hase, Niwrutti K.& Kumar, Rajesh& Dedhia, Paras& Jamale, Tukaram& Bajpai, Divya. Predictors of coronary calcification in Indian hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 4, pp.822-827.
https://search.emarefa.net/detail/BIM-896523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 827
Record ID
BIM-896523