Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes
Joint Authors
al-Asuli, Sufyan Muhammad
Qari, Samir Hasan M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 1 (31 Jan. 2019), pp.91-95, 5 p.
Publisher
Publication Date
2019-01-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The current study was carried out to evaluate the genotoxic aspects of the aqueous extracts of the Tribulus terrestris fruits by comet assay and cytogenetic procedures conditions on cultured human peripheral blood lymphocyte.
After the treatment of the lymphocytes with four concentrations of the aqueous fruit extract of T.
terrestris (10, 20, 40 and 80 mg/L) for 24 h it was noticed that, the presence of micronuclei and/or chromosomal aberration were monitored and a significant increase of comet cells at high concentration of T.
terrestris extract 80 mg/L.
Also, this study showed that the presence of micronuclei, chromosomal aberration as a chromosomal gap, fragmentation, stickiness and necrotic cells were appeared and increased with high concentrations of T.
terrestris fruits extract (40–80 mg/L).
On the other hand, no significant difference was observed with the low concentration of the extract (10–20 mg/L) as compared with control.
The current study refers to the ability of the extract of T.
terrestris fruits to do damage in the target DNA at the higher concentrations.
Thus, it could be considered that the aqueous extracts of the T.
terrestris fruits have genotoxic effect in the therapeutic protocols if it used in high doses.
American Psychological Association (APA)
Qari, Samir Hasan M.& al-Asuli, Sufyan Muhammad. 2019. Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.91-95.
https://search.emarefa.net/detail/BIM-896647
Modern Language Association (MLA)
Qari, Samir Hasan M.& al-Asuli, Sufyan Muhammad. Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.91-95.
https://search.emarefa.net/detail/BIM-896647
American Medical Association (AMA)
Qari, Samir Hasan M.& al-Asuli, Sufyan Muhammad. Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.91-95.
https://search.emarefa.net/detail/BIM-896647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 95
Record ID
BIM-896647