Evaluation of LL 37 lipoprotein as innate immunity marker among Sudanese patients cutaneous Leishmania
Joint Authors
Bakr, Ayat H.
Abu Grun, E. A.
Abd Rabbih, Abd al-Karim A.
Muhammad, Umaymah A.
Mukhtar, M. A.
Mudawi, Jad Allah
Source
Sudan Journal of Medical Sciences
Issue
Vol. 14, Issue 3 (30 Sep. 2019), pp.91-96, 6 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2019-09-30
Country of Publication
Sudan
No. of Pages
6
Main Subjects
Abstract EN
Background: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania.
LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein.
The most prominent function of cathelicidin is their ability to inhibit propagation of a diverse range of microorganisms, which occurs at a micromolar range.
Objective: The study was aimed to evaluate the LL37 plasma level in Leishmania Sudanese patients.
Methods: In a case-control study, 300 subjects were enrolled (200 as case and 100 controls); 5 ml venous blood was collected in EDTA container, then plasma was obtained and stored frozen at –80°C.
LL 37 was estimated using competitive ELISA.
The data were analyzed using SPSS version 21.
Results: The results revealed that 115 (57%) of Leishimania patients were male and 85 (43%) were female.
Plasma LL 37 level was significantly increased in Leishmania patients (1.30 ± 0.71) compared to the control (0.21 ± 0.20) with (p-value 0.000).
Conclusion: Leishmania patients had higher levels of plasma LL37, suggesting effective antimicrobial immunity process enhancing healing of cutaneous leishmaniasis.
American Psychological Association (APA)
Bakr, Ayat H.& Abu Grun, E. A.& Abd Rabbih, Abd al-Karim A.& Muhammad, Umaymah A.& Mukhtar, M. A.& Mudawi, Jad Allah. 2019. Evaluation of LL 37 lipoprotein as innate immunity marker among Sudanese patients cutaneous Leishmania. Sudan Journal of Medical Sciences،Vol. 14, no. 3, pp.91-96.
https://search.emarefa.net/detail/BIM-898889
Modern Language Association (MLA)
Bakr, Ayat H.…[et al.]. Evaluation of LL 37 lipoprotein as innate immunity marker among Sudanese patients cutaneous Leishmania. Sudan Journal of Medical Sciences Vol. 14, no. 3 (2019), pp.91-96.
https://search.emarefa.net/detail/BIM-898889
American Medical Association (AMA)
Bakr, Ayat H.& Abu Grun, E. A.& Abd Rabbih, Abd al-Karim A.& Muhammad, Umaymah A.& Mukhtar, M. A.& Mudawi, Jad Allah. Evaluation of LL 37 lipoprotein as innate immunity marker among Sudanese patients cutaneous Leishmania. Sudan Journal of Medical Sciences. 2019. Vol. 14, no. 3, pp.91-96.
https://search.emarefa.net/detail/BIM-898889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 95-96
Record ID
BIM-898889