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Indirect spectrophotometric determination of niclosamide in pharmaceutical preparations
Joint Authors
Sultan, Sad H.
Uthman, Nabil S.
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 27, Issue 3 (30 Sep. 2018), pp.1-18, 18 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2018-09-30
Country of Publication
Iraq
No. of Pages
18
Main Subjects
Abstract EN
A simple and sensitive indirect spectrophotometric method is developed for the determination of niclosamide in pharmaceutical preparations.
The method is based on the oxidation of reduced form of niclosamide with iron ( III ) in acidic medium, then the subsequent reaction of iron ( II ) with 1,10- phenanthroline to produce a ferroin complex which is water - soluble , stable (using EDTA solution improve the stability of the complex) , and has a maximum absorption at 510 nm against the reagent blank with a molar absorptivity of 2.19×104 l.mol-1 .cm -1 .
Beer,s law is valid over the concentration range of 2.5 to 225 µg/10 ml.
The relative error is in between - 1.80 and +1.50 % and the relative standard deviation from ± 0.89 to ± 2.07 % depending on the concentration of niclosamide .
The proposed method has been applied successfully to determine niclosamide in pharmaceutical preparations.
American Psychological Association (APA)
Uthman, Nabil S.& Sultan, Sad H.. 2018. Indirect spectrophotometric determination of niclosamide in pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 27, no. 3, pp.1-18.
https://search.emarefa.net/detail/BIM-899676
Modern Language Association (MLA)
Uthman, Nabil S.& Sultan, Sad H.. Indirect spectrophotometric determination of niclosamide in pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 27, no. 3 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-899676
American Medical Association (AMA)
Uthman, Nabil S.& Sultan, Sad H.. Indirect spectrophotometric determination of niclosamide in pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2018. Vol. 27, no. 3, pp.1-18.
https://search.emarefa.net/detail/BIM-899676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 17-18
Record ID
BIM-899676