Occurrence of hypothyroidism, diabetes mellitus, and celiac disease in emirate children with down’s syndrome
Joint Authors
Abd al-Razzaq, Yusuf
al-Azzabi, Tariq I.
al-Hamid, Sania M.
Atiyyah, Salimah
Dib, Asma'a
Abu Rawi, al-Hadi H.
Source
Issue
Vol. 33, Issue 5 (30 Sep. 2018), pp.387-392, 6 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Oman
No. of Pages
6
Main Subjects
Abstract EN
Objectives: Autoimmune diseases are known to occur in people with Down’s syndrome (DS), especially celiac disease, type 1 diabetes mellitus (DM), and hypothyroidism.
Since there are common genetic risk factors involved in the occurrence of these autoimmune disorders, the risks would differ in different populations.
We sought to determine the prevalence of type 1 DM, celiac disease, and hypothyroidism in Emirati patients with DS in Abu Dhabi, UAE.
Methods: Ninety-two patients with DS were investigated for the presence of anti-thyroid antibodies, antithyroglobulin, and anti-thyroid peroxidase antibodies for hypothyroidism, anti-glutamic acid decarboxylase antibodies for type 1 DM, and anti-tissue transglutaminase immunoglobulin A antibodies for celiac disease.
Results: Karyotyping was performed on 89 patients.
Eighty-seven had nondisjunction of chromosome 21 (97.8%), one was a mosaic, and one had translocation.
Of the patients studied, 19.6% had hypothyroidism, 4.3% had type 1 DM, and 1.1% had celiac disease.
Out of the 92 patients studied, 66 (71.7%) did not have any autoimmune disease, 25 (27.2%) had one autoimmune disease, and one (1.1%) had two autoimmune diseases.
Conclusions: Celiac disease was the least prevalent autoimmune disease in patients with DS patients, while type 1 DM and hypothyroidism were both significantly associated with DS.
American Psychological Association (APA)
Abd al-Razzaq, Yusuf& al-Azzabi, Tariq I.& al-Hamid, Sania M.& Atiyyah, Salimah& Dib, Asma'a& Abu Rawi, al-Hadi H.. 2018. Occurrence of hypothyroidism, diabetes mellitus, and celiac disease in emirate children with down’s syndrome. Oman Medical Journal،Vol. 33, no. 5, pp.387-392.
https://search.emarefa.net/detail/BIM-902498
Modern Language Association (MLA)
Abd al-Razzaq, Yusuf…[et al.]. Occurrence of hypothyroidism, diabetes mellitus, and celiac disease in emirate children with down’s syndrome. Oman Medical Journal Vol. 33, no. 5 (Sep. 2018), pp.387-392.
https://search.emarefa.net/detail/BIM-902498
American Medical Association (AMA)
Abd al-Razzaq, Yusuf& al-Azzabi, Tariq I.& al-Hamid, Sania M.& Atiyyah, Salimah& Dib, Asma'a& Abu Rawi, al-Hadi H.. Occurrence of hypothyroidism, diabetes mellitus, and celiac disease in emirate children with down’s syndrome. Oman Medical Journal. 2018. Vol. 33, no. 5, pp.387-392.
https://search.emarefa.net/detail/BIM-902498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 391-392
Record ID
BIM-902498