A comparative study of the effect of oral dextromethorphan and placebo on the pain after vitrectomy surgery : a double-blind, placebo-controlled, randomized clinical trial
Joint Authors
Nikoubakht, Nasim
Sayarifard, Azadeh
Fayiz, Sayyid Hamid Rida
Rahimzadeh, Poupak
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 12 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Publication Date
2018-12-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background: Postoperative pain is a major complication in patients undergoing eye surgery.
N-methyl-D-aspartate (NMDA) receptor antagonists are widely used to manage postoperative pains.
Dextromethorphan, as an NMDA antagonist, is commonly used as an oral drug.
Objectives: This study was conducted to evaluate the effect of Dextromethorphan on post-operation pain and sedative effect in comparison to placebo.
Methods: A double-blinded, placebo-controlled, randomized clinical trial, upon 60 patients undergoing vitrectomy surgery was done.
Thirty patients received 30 mg oral Dextromethorphan before the operation, and 30 patients received a placebo.
Postoperation pain and sedation were evaluated after zero, one, two, and six hours.
Results: Post-operation pain was significantly lower in patients who received Dextromethorphan at zero, one, and two hours after operation (P < 0.001); however, not at six hours after operation (P = 0.11).
Sedative effect was higher in the Dextromethorphan group at zero (P = 0.03) and one hour (P = 0.01) after operation.
Conclusions: Prescribing oral Dextromethorphan before a vitrectomy surgery could reduce postoperative pain.
It also has postoperative sedation effects
American Psychological Association (APA)
Fayiz, Sayyid Hamid Rida& Nikoubakht, Nasim& Sayarifard, Azadeh& Rahimzadeh, Poupak. 2018. A comparative study of the effect of oral dextromethorphan and placebo on the pain after vitrectomy surgery : a double-blind, placebo-controlled, randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-909115
Modern Language Association (MLA)
Fayiz, Sayyid Hamid Rida…[et al.]. A comparative study of the effect of oral dextromethorphan and placebo on the pain after vitrectomy surgery : a double-blind, placebo-controlled, randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 12 (Dec. 2018), pp.1-6.
https://search.emarefa.net/detail/BIM-909115
American Medical Association (AMA)
Fayiz, Sayyid Hamid Rida& Nikoubakht, Nasim& Sayarifard, Azadeh& Rahimzadeh, Poupak. A comparative study of the effect of oral dextromethorphan and placebo on the pain after vitrectomy surgery : a double-blind, placebo-controlled, randomized clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-909115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-909115