Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits
Other Title(s)
الكشف تجريبيا عن تأثير مستخلص بذور العنب كمضاد للأكسدة و مضاد للتعصد في الأرانب
Joint Authors
al-Bajjari, Shihab Ahmad
al-Akkash, Mutazz Adil
Ismail, Hana Khalil
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 33, Issue 2 (31 Dec. 2019), pp.243-249, 7 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
The aim of this study was to determine the ability of Grapes seeds (Vitis vinifera) aqueous, proteinous, non- proteinous and alcoholic extracts as antioxidant and antiatherogenic in rabbits after exposure to 0.5% H2O2 in drinking water for 30 days.
The results illustrated capability of 0.5% H2O2 to initiate oxidative stress via significant decrease in Glutathione (GSH), glutathione peroxdiase (GPx), Catalase (CAT) and superoxide dismutase (SOD) level in heart and liver concomitant with significant increase in malondialhyde (MDA) in addition to decrease in high density lipoprotein- cholesterol (HDL-c) and increase low density lipoprotein- cholesterol (LDL-c) in serum of treated only with H2O2 rabbits.
While rabbits treated with H2O2 associated with Grapes seeds (aqueous, proteinous, non- proteinous and alcohol) extracts for 15 days showed a significant increase of Glutathione (GSH), glutathione peroxdiase (GPx), superoxide dismutase (SOD) concentration in the heart and liver tissue as well as increase HDL-c, decrease in LDL-c and VLDL-c.
While, the histolopathological examination of heart and liver tissue demonstrated that H2O2 induces, degeneration, necrosis and few inflammation foci in the liver and myocardial muscle.
While the administration of (Vitis vinifera) aqueous, proteinous, non-proteinous and alcoholic extracts cause improvement in the histological picture of the liver and the myocardial muscle.
It was concluded that the (Grapes extracts) aqueous, proteinous, non-proteinous and especially the alcoholic extracts can reduce the damage caused by H2O2 and this will pave the way to investigate the protective effects of the natural substances in the diseases caused by oxidative stress.
American Psychological Association (APA)
al-Bajjari, Shihab Ahmad& al-Akkash, Mutazz Adil& Ismail, Hana Khalil. 2019. Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits. Iraqi Journal of Veterinary Sciences،Vol. 33, no. 2, pp.243-249.
https://search.emarefa.net/detail/BIM-917109
Modern Language Association (MLA)
al-Bajjari, Shihab Ahmad…[et al.]. Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits. Iraqi Journal of Veterinary Sciences Vol. 33, no. 2 (2019), pp.243-249.
https://search.emarefa.net/detail/BIM-917109
American Medical Association (AMA)
al-Bajjari, Shihab Ahmad& al-Akkash, Mutazz Adil& Ismail, Hana Khalil. Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits. Iraqi Journal of Veterinary Sciences. 2019. Vol. 33, no. 2, pp.243-249.
https://search.emarefa.net/detail/BIM-917109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 248-249
Record ID
BIM-917109