Phytochemical profiling, antioxidant and HepG2 cancer cells antiproliferation potential in the kernels of apricot cultivars
Joint Authors
Chen, Yongsheng
al-Shaykh, Muhammad Sulayman
Shah, Munir H.
al-Dusari, Munirah A.
Abbasi, Arshad Mahmud
al-Ghamidi, Abd Allah Ahmad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 27, Issue 1 (31 Jan. 2020), pp.163-172, 10 p.
Publisher
Publication Date
2020-01-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Phytochemical composition, in vitro antioxidant and antiproliferative activity against HepG2 cells were studied in the kernels of apricot cultivars grown in the northern areas of Pakistan.
Relatively, the kernel of Habbi cultivar/AP-12 depicted significant potential to scavenge DPPH and ABTS+ free radicals as well as oxygen radical absorbance capacity along with highest contents of total flavonoids, phenolics, chlorogenic and syringic acids on dry weight basis.
The average concentration of quercetin ranged 0.072–1.343 mg/100 g, and of EGCG from 0.713 to 6.521 mg/100 g with maximum concentration in Hulappa/AP-3 and Kho Chali-Khatta 3/AP-17, respectively.
Amygdalin content was highest (1145 mg/100 g) in the kernel of Balaani/AP-14.
Highest inhibition of HepG2 cells was found in the kernel of Waflu Chuli/AP-9 (EC50 = 15.70 ± 3.77 mg/mL).
The PCA showed significant contributions of polyphenols and flavonoids towards biochemical assays, while CA revealed similarities and associations among various cultivars.
Our study revealed that Habbi, Waflu Chuli, Thukdeena and Balaani kernels are rich sources of bioactive compounds and possess significant antioxidant and anticancer activity and can contribute considerably in the prevention and treatment of chronic health disorders.
American Psychological Association (APA)
al-Ghamidi, Abd Allah Ahmad& al-Shaykh, Muhammad Sulayman& Shah, Munir H.& al-Dusari, Munirah A.& Abbasi, Arshad Mahmud& Chen, Yongsheng. 2020. Phytochemical profiling, antioxidant and HepG2 cancer cells antiproliferation potential in the kernels of apricot cultivars. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.163-172.
https://search.emarefa.net/detail/BIM-920505
Modern Language Association (MLA)
Chen, Yongsheng…[et al.]. Phytochemical profiling, antioxidant and HepG2 cancer cells antiproliferation potential in the kernels of apricot cultivars. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.163-172.
https://search.emarefa.net/detail/BIM-920505
American Medical Association (AMA)
al-Ghamidi, Abd Allah Ahmad& al-Shaykh, Muhammad Sulayman& Shah, Munir H.& al-Dusari, Munirah A.& Abbasi, Arshad Mahmud& Chen, Yongsheng. Phytochemical profiling, antioxidant and HepG2 cancer cells antiproliferation potential in the kernels of apricot cultivars. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.163-172.
https://search.emarefa.net/detail/BIM-920505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 171-172
Record ID
BIM-920505