![](/images/graphics-bg.png)
In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea
Joint Authors
Ashraf, Kamran
Sultan, Sadia
Halim, Hasseri
Lim, Siong Meng
Ramasamy, Kalavathy
Source
Saudi Journal of Biological Sciences
Issue
Vol. 27, Issue 1 (31 Jan. 2020), pp.417-432, 16 p.
Publisher
Publication Date
2020-01-31
Country of Publication
Saudi Arabia
No. of Pages
16
Main Subjects
Topics
Abstract EN
Background Medicinal plants are important source of drugs with pharmacological activities.
Therefore, there is always rising demands to discover more therapeutic agents from various species.
Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea are high valued medicinal plants of Malaysia contain rich source of phenolic and flavonoid compounds.
The aims of the present study were to evaluate anti-oxidant, antimicrobial and anti-proliferative effects on A549, HePG2 and MCF7 cell lines of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea.
Methodology The leaves of all selected plants were extracted with methanol, chloroform, ethyl acetate and butanol separately with simple cold maceration.
Antioxidant activity of all crude extracts were quantitatively measured against DPPH and Ferric Reducing Assay.
Antimicrobial evaluation was done by Microdilution and MTT assay and antipoliferative activity of all extracts of selected plant were evaluated against A549, HePG2 and MCF7 cell lines.
Results Results showed that methanol extract exhibited highest percentage free radical scavenging activity of almost all extracts of selected plants.
Antimicrobials results showed chloroform and methanol extracts of O.
stamineus extract were the two most active extracts against resistant MRSA but not S.
aureus.
Only methanol extract of G.
procumbens showed antimicrobial activity against the tested pathogens.
Chloroform and methanol extracts of F.
deltoidea elicited antimicrobial activity against S.
aureus but not MRSA.
Antiproliferative activity against three tested cell lines results showed that ethyl acetate extract of O.
stamineus showed good effect whereas methanol extract of F.
deltoidea and G.
procumbens exhibited good antiproliferative activity.
Conclusions The results of the present investigation demonstrated significant variations in the antioxidant, antimicrobial and antiproliferative effects of different solvent extracts.
These data could be helpful in isolation of pure potent compounds with good biological activities from the extracts of plants.
American Psychological Association (APA)
Ashraf, Kamran& Halim, Hasseri& Lim, Siong Meng& Ramasamy, Kalavathy& Sultan, Sadia. 2020. In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.417-432.
https://search.emarefa.net/detail/BIM-920707
Modern Language Association (MLA)
Ashraf, Kamran…[et al.]. In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.417-432.
https://search.emarefa.net/detail/BIM-920707
American Medical Association (AMA)
Ashraf, Kamran& Halim, Hasseri& Lim, Siong Meng& Ramasamy, Kalavathy& Sultan, Sadia. In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.417-432.
https://search.emarefa.net/detail/BIM-920707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 431-432
Record ID
BIM-920707