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Association study of HSD11B1 rs12086634 (T>G) gene polymorphism with polycystic ovarian syndrome in Erbil Province
Joint Authors
Sharif, Abd Allah Abu Bakr
al-Attar, Mustafa Sabir
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 31, Issue 5 (31 Oct. 2019), pp.36-43, 8 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2019-10-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent gynaecological imbalances of endocrine hormones and metabolic disorders that affect women during puberty, with a prevalence of up to 17.8%.
Objective: The current study focused on the presence of rs12086634 T>G genetic variant of 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism in Erbil province PCOS women.
Participants and methods: The present study was conducted on 104 PCOS women and 94 control women to investigate the association HSD11B1 rs12086634 (T>G) gene polymorphism with PCOS.
The extracted genomic DNA from whole blood according to the protocol provided by the manufacturer company.
HSD11B1 rs12086634 T>G gene polymorphism was detected by tetra primer-amplification refractory mutation system based polymerase chain reaction (T-ARMS-PCR) method.
Result: The obtained results suggest that the frequency of the HSD11B1 TG and GG genotypes in women with PCOS increased 3.60-fold and 4.39-fold compared to the control group (odds ratio [OR]; 3.60 and 4.39, 95% confidence interval [CI], 1.951-6.668 and 0.175-110.2; P-value <0.0001 and 0.22) respectively, the body mass index of women with G-allele was significantly greater than women with T-Allele (28.32 kg/ mt2 vs.
26.20 kg/ mt2,and p = 0.0256).
Conclusions: Our findings indicated and proved that the findings indicate that both homozygous and heterozygous genotypes of HSD11B1 rs12086634 T>G gene polymorphism was associated with PCOS in Erbil province.
American Psychological Association (APA)
Sharif, Abd Allah Abu Bakr& al-Attar, Mustafa Sabir. 2019. Association study of HSD11B1 rs12086634 (T>G) gene polymorphism with polycystic ovarian syndrome in Erbil Province. ZANCO Journal of Pure and Applied Sciences،Vol. 31, no. 5, pp.36-43.
https://search.emarefa.net/detail/BIM-947638
Modern Language Association (MLA)
Sharif, Abd Allah Abu Bakr& al-Attar, Mustafa Sabir. Association study of HSD11B1 rs12086634 (T>G) gene polymorphism with polycystic ovarian syndrome in Erbil Province. ZANCO Journal of Pure and Applied Sciences Vol. 31, no. 5 (2019), pp.36-43.
https://search.emarefa.net/detail/BIM-947638
American Medical Association (AMA)
Sharif, Abd Allah Abu Bakr& al-Attar, Mustafa Sabir. Association study of HSD11B1 rs12086634 (T>G) gene polymorphism with polycystic ovarian syndrome in Erbil Province. ZANCO Journal of Pure and Applied Sciences. 2019. Vol. 31, no. 5, pp.36-43.
https://search.emarefa.net/detail/BIM-947638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 41-43
Record ID
BIM-947638