Estimation of MDA, CRP and some hematological parameters in the mature Cypriot thalassemia patients

Abstract EN

Thalassemia is a blood disorder has been known to passes down by parent to their offspring.

The root of this disorder mainly returns to the Mediterranean Countries.

Degradation of erythrocytes results in a thalassemia disease as a result of producing defeated Hemoglobin Molecules, due to changes occurring in their DNA structure like insertion or deletion.

For decades the only medical treatment those patients had is getting blood gave way by healthy volunteers.

As a result of this process, they receive lots of Iron minerals possibly causing oxidative Stress, Inflammation and splenomegaly.

The aim of the present work aimed to estimate the C-Reactive Proteins (CRP) as Biomarker of Inflammation, Serum Ferritin as Biomarker of Iron overload and MDA as A biomarker of oxidative Stress in patients B- thalassemia then comparing their data to healthy normal volunteers.

The study group consisted of 24 thalassemia patients and 24 control groups.

The blood samples of β-thalassemia cases were collected in thalassemia center In Dr.Burhan Nalbantoğlu Government Hospital/ Cyprus.

After centrifugation, Aliquots of serum and plasma has been stored for the later estimation CRP, MDA and serum ferritin.

Our data shows that the levels of C-reactive protein (1.350 ± 1.142 vs 0.325 ± 0.398; p<0.001), MDA (7.734 ± 1.557 vs 5.638 ± 1.219; p<0.001) and serum ferritin (617.92 ± 238.63 vs 433.82 ± 228.61; p=0.016) were significantly greater in contrast to same parameters of healthy controls.

overall, our study proved again that examining levels of CRP, MDA and serum ferritin could serve as good indicators of the risks possibly faces those patients, knowledge about the status of those parameters could offer Some Helpful Knowledge assisting health professionals in better management patients with β-Thalassemia.