Correlations between selenium levels and diabetes mellitus type 2 in chronic hepatitis c-infected patients

Abstract EN

Background : Plasma selenium (Se) concentrations corresponding to optimal health are highly dynamic and based on a combination of factors that need to be considered when assessing epidemiological data, such as the findings linking serum Se and type 2 diabetes mellitus (DM).

High serum Se concentrations may be associated with a higher occurrence of diabetes.

Aim: To evaluate the correlations between serum Se levels and DM in pa-tients with chronic Hepatitis C (CHC).

Patients and Methods : This case-control study in-cluded three groups; group 1 (29 CHC patients with DM), group 2 (29 CHC patients with-out DM) and group 3 (29 healthy control).

Subjects were tested for biochemical liver function tests, fasting blood sugar [FBS], and fasting insulin levels).

Homeostasis model assessment (HOMA)-insulin resistance (IR) was calculated.

Se levels were measured us-ing Atomic Absorption Spectroscopy.

Results: serum Se were significantly higher in group 1 and group 3 compared to group 2 (p < 0.01).

Meanwhile, serum Se were insignifi-cantly higher in group 1 than in group 3 (p > 0.05).

Cutoff value to differentiate diabetic and non-diabetic CHC patients using serum Se was >10 μg/l with sensitivity (76 %) and, specificity (86.2 %).

The incidence and the risk of Se deficiency were significantly higher among group 2 than among group 2 (24.1% vs.

3.4 %, respectively) (p < 0.05).

In entire CHC patients (group 1+group 2), the mean HOMA-IR values were significantly lower in the group with deficient Se levels than in the group with normal Se levels (p = 0.005).

A nega-tive correlations between serum Se levels and ALT levels, AST levels, and diabetes treat-ment was found.

Conclusions : Serum Se levels were significantly higher in CHC + DM group and in control group than in CHC group.

The incidence and the risk of Se deficiency were higher among HCV group compared to CHC + DM group.