Correlations between selenium levels and diabetes mellitus type 2 in chronic hepatitis c-infected patients
Joint Authors
al-Khawajah, Salwa E.
Abd Allah, Isam M.
al-Shabrawi, Muhammad M.
Sulayman, Nashat M.
Source
Suez Canal University Medical Journal
Issue
Vol. 19, Issue 1 (30 Jun. 2016), pp.48-59, 12 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background : Plasma selenium (Se) concentrations corresponding to optimal health are highly dynamic and based on a combination of factors that need to be considered when assessing epidemiological data, such as the findings linking serum Se and type 2 diabetes mellitus (DM).
High serum Se concentrations may be associated with a higher occurrence of diabetes.
Aim: To evaluate the correlations between serum Se levels and DM in pa-tients with chronic Hepatitis C (CHC).
Patients and Methods : This case-control study in-cluded three groups; group 1 (29 CHC patients with DM), group 2 (29 CHC patients with-out DM) and group 3 (29 healthy control).
Subjects were tested for biochemical liver function tests, fasting blood sugar [FBS], and fasting insulin levels).
Homeostasis model assessment (HOMA)-insulin resistance (IR) was calculated.
Se levels were measured us-ing Atomic Absorption Spectroscopy.
Results: serum Se were significantly higher in group 1 and group 3 compared to group 2 (p < 0.01).
Meanwhile, serum Se were insignifi-cantly higher in group 1 than in group 3 (p > 0.05).
Cutoff value to differentiate diabetic and non-diabetic CHC patients using serum Se was >10 μg/l with sensitivity (76 %) and, specificity (86.2 %).
The incidence and the risk of Se deficiency were significantly higher among group 2 than among group 2 (24.1% vs.
3.4 %, respectively) (p < 0.05).
In entire CHC patients (group 1+group 2), the mean HOMA-IR values were significantly lower in the group with deficient Se levels than in the group with normal Se levels (p = 0.005).
A nega-tive correlations between serum Se levels and ALT levels, AST levels, and diabetes treat-ment was found.
Conclusions : Serum Se levels were significantly higher in CHC + DM group and in control group than in CHC group.
The incidence and the risk of Se deficiency were higher among HCV group compared to CHC + DM group.
American Psychological Association (APA)
Sulayman, Nashat M.& al-Khawajah, Salwa E.& Abd Allah, Isam M.& al-Shabrawi, Muhammad M.. 2016. Correlations between selenium levels and diabetes mellitus type 2 in chronic hepatitis c-infected patients. Suez Canal University Medical Journal،Vol. 19, no. 1, pp.48-59.
https://search.emarefa.net/detail/BIM-959126
Modern Language Association (MLA)
Sulayman, Nashat M.…[et al.]. Correlations between selenium levels and diabetes mellitus type 2 in chronic hepatitis c-infected patients. Suez Canal University Medical Journal Vol. 19, no. 1 (2016), pp.48-59.
https://search.emarefa.net/detail/BIM-959126
American Medical Association (AMA)
Sulayman, Nashat M.& al-Khawajah, Salwa E.& Abd Allah, Isam M.& al-Shabrawi, Muhammad M.. Correlations between selenium levels and diabetes mellitus type 2 in chronic hepatitis c-infected patients. Suez Canal University Medical Journal. 2016. Vol. 19, no. 1, pp.48-59.
https://search.emarefa.net/detail/BIM-959126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 57-59
Record ID
BIM-959126