Predictors of induction and sustainability of response to diuretic therapy in patients with decompensated chronic liver disease
Joint Authors
Hasan, Muhammad F.
al-Shaturi, Muhammad A.
Ali, Hana E.
Khidr, Muhammad Salah al-Din
Source
Suez Canal University Medical Journal
Issue
Vol. 21, Issue 1 (30 Jun. 2018), pp.18-23, 6 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2018-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background: Factors involved in individual’s response to loop diuretics in cirrhotic patients with ascites are many, which renders it difficult to austerely predict response to diuretic therapy in those patients.
The aim of this study was to evaluate factors which determine initial response to loop diuretic therapy in those patients and to determine whether such factors can predict a sustained diuresis response.
Patients and Methods: One hundred and ten patients with non-malignant chronic liver disease and ascites were treated with IV furosemide in doses according to serum creatinine together with oral spironolactone 50mg twice daily.
Before and during the diuretic therapy a set of clinical and laboratory variables were investigated as possible predictive factors influencing the therapeutic response to diuretics.
The renal arterial resistive index (RI) (reflecting renal vascular resistance) was estimated with duplex Doppler ultrasonography.
Results: Our study revealed statistically significant relation between high ascites grade(p=0.013), higher Child-Pugh class (p< 0.001), higher baseline serum creatinine & lower eGFR (p< 0.001), and high renal resistive index (p=0.002) with poor diuretic response.
Conclusion: combining both clinical and laboratory findings together with elevated baseline renal resistive index would be helpful in early identification of the subgroup of patients who are at higher risk of diuretic resistance.
American Psychological Association (APA)
Khidr, Muhammad Salah al-Din& Hasan, Muhammad F.& al-Shaturi, Muhammad A.& Ali, Hana E.. 2018. Predictors of induction and sustainability of response to diuretic therapy in patients with decompensated chronic liver disease. Suez Canal University Medical Journal،Vol. 21, no. 1, pp.18-23.
https://search.emarefa.net/detail/BIM-963674
Modern Language Association (MLA)
Khidr, Muhammad Salah al-Din…[et al.]. Predictors of induction and sustainability of response to diuretic therapy in patients with decompensated chronic liver disease. Suez Canal University Medical Journal Vol. 21, no. 1 (2018), pp.18-23.
https://search.emarefa.net/detail/BIM-963674
American Medical Association (AMA)
Khidr, Muhammad Salah al-Din& Hasan, Muhammad F.& al-Shaturi, Muhammad A.& Ali, Hana E.. Predictors of induction and sustainability of response to diuretic therapy in patients with decompensated chronic liver disease. Suez Canal University Medical Journal. 2018. Vol. 21, no. 1, pp.18-23.
https://search.emarefa.net/detail/BIM-963674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 23
Record ID
BIM-963674