Biological activities of Iraqi fig (Ficuscarica) crude ethanolic and total flavonoids extracts
Other Title(s)
الفعالية الحيوية لمستخلص الكحولي الخام و مستخلص الف لافونويدات الكلية لنبات التين العراقي
Joint Authors
Hasan, Zaynab Yasin Muhammad
Abd al-Hamid, Bara Abd al-Hadi
Muhammad, Faruq Ibrahim
al-Halbusi, Muhammad Mahmud Farhan
Source
Issue
Vol. 61, Issue 7 (31 Jul. 2020), pp.1612-1621, 10 p.
Publisher
University of Baghdad College of Science
Publication Date
2020-07-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
The present study focuses on the biological strategy for treating cancer and parasitic infections, such as leishmaniasis antiparasitic activity, forthe crude alcoholic extract ofFicus leaves and their extracted total flavonoids with a comparison between their effects.The flavonoids were extracted from the leaves of the mature Ficuscaricausing the reflux extraction method.
Total flavonoids were detected qualitatively by TLC techniquewhich demonstratedthat the plant was rich indifferent flavonoids, especially Rutin, Quercetin, Kaempferol, luteolin and others.
Quantitatively, the plant total flavonoids content was 337.3 mg / 100 g fig leaves calculated as rutin.The biologicaleffects of the crude and purified total flavonoid on cell lines (L-20B and MCF7) and two parasites (Leishmaniatropica ,Leishmaniadonvani) were investigated.
Maximum growthinhibition rates forthe total flavonoids onthe cell linesL20B andMCF7 reached 43 % at the concentration of 0.169 mg/ml and 28% at the concentration of 2.7 mg/ml, respectively, in comparison with the negative control.
The ethanoliccrude extract had a low effect on L20-B cell line, while the inhibition rate forMCF-7 cell linereached 34% at a concentration of 0.084 mg/ml.
For Leishmaniatropica,the total flavonoid and crude plant extractcaused maximum inhibition rates of 48% and 56%, respectively,at a concentration of 2.7 mg/ml for both.
Cytotoxicity valueon Leshmaniadonovani was 20% for the crude extract at 1.35 mg/ml concentration, whereas it was11% for the total flavonoids at a concentration of 0.169 mg/ml.
In conclusion, the differences in anticancer and anti-parasitic activitiesareattributed to differentcompounds present in each extract.
American Psychological Association (APA)
al-Halbusi, Muhammad Mahmud Farhan& Hasan, Zaynab Yasin Muhammad& Muhammad, Faruq Ibrahim& Abd al-Hamid, Bara Abd al-Hadi. 2020. Biological activities of Iraqi fig (Ficuscarica) crude ethanolic and total flavonoids extracts. Iraqi Journal of Science،Vol. 61, no. 7, pp.1612-1621.
https://search.emarefa.net/detail/BIM-970112
Modern Language Association (MLA)
al-Halbusi, Muhammad Mahmud Farhan…[et al.]. Biological activities of Iraqi fig (Ficuscarica) crude ethanolic and total flavonoids extracts. Iraqi Journal of Science Vol. 61, no. 7 (2020), pp.1612-1621.
https://search.emarefa.net/detail/BIM-970112
American Medical Association (AMA)
al-Halbusi, Muhammad Mahmud Farhan& Hasan, Zaynab Yasin Muhammad& Muhammad, Faruq Ibrahim& Abd al-Hamid, Bara Abd al-Hadi. Biological activities of Iraqi fig (Ficuscarica) crude ethanolic and total flavonoids extracts. Iraqi Journal of Science. 2020. Vol. 61, no. 7, pp.1612-1621.
https://search.emarefa.net/detail/BIM-970112
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-970112