Preparation, characterization, and nitrofurantion release study of (casein sodium alginate) microparticles
Other Title(s)
تحضير و تشخيص و دراسة تحرر دواء النتروفورانتوين من الجسيمات الدقيقة (الكازين الجينيت الصوديوم)
Joint Authors
Kamil, Sarah Arif
al-Asadi, Nadiyah Ashur Husayn
Source
Journal of Basrah Researches : Sciences
Issue
Vol. 46, Issue 1 (31 Mar. 2020), pp.148-159, 12 p.
Publisher
University of Basrah College of Education for Pure Sciences
Publication Date
2020-03-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract EN
Casein microparticales including different amounts of sodium alginate were prepared by a solvent evaporation technique, using a (crosslinking) agent.
Microparticles were characterized based on the surface morphology, size Distribution, by photomicrographs microscopy and (FT-IR) spectroscopy.
Microparticles diameters ranged between (44 - 94.
4) µm.
The microparticles were also evaluated in-vitro release and kinetics release of Nitrofurantoin (NFT), as a model of the drug.
The results displayed that the ratios of released the NFT increase as the concentration of the loaded NFT increases on the Microparticles, and the results also show that with an increase in the Casein, sodium alginate concentration, the NFT release from the Microparaticles decreases.
The (R2) of determination-indicated that the release-data was within the movement of the zero order and the Higuchi equation explains that the release of the NFT is carried out according to the mechanism of diffusion.
Finally, The results showed that (biological efficiency) for microparticle loaded with NFT exceed biological efficiency against two type bacterial Escherichia coli, Staphylococcus aurous and one fungal Candida albicans, .
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American Psychological Association (APA)
Kamil, Sarah Arif& al-Asadi, Nadiyah Ashur Husayn. 2020. Preparation, characterization, and nitrofurantion release study of (casein sodium alginate) microparticles. Journal of Basrah Researches : Sciences،Vol. 46, no. 1, pp.148-159.
https://search.emarefa.net/detail/BIM-973028
Modern Language Association (MLA)
Kamil, Sarah Arif& al-Asadi, Nadiyah Ashur Husayn. Preparation, characterization, and nitrofurantion release study of (casein sodium alginate) microparticles. Journal of Basrah Researches : Sciences Vol. 46, no. 1 (2020), pp.148-159.
https://search.emarefa.net/detail/BIM-973028
American Medical Association (AMA)
Kamil, Sarah Arif& al-Asadi, Nadiyah Ashur Husayn. Preparation, characterization, and nitrofurantion release study of (casein sodium alginate) microparticles. Journal of Basrah Researches : Sciences. 2020. Vol. 46, no. 1, pp.148-159.
https://search.emarefa.net/detail/BIM-973028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 158
Record ID
BIM-973028